DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr‐carrying Bacteria Through a Negative Feedback Regulatory Mechanism

DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr‐carrying Bacteria Through a Negative Feedback Regulatory Mechanism

Abstract The plasmid‐borne resistance gene mcr drastically undermines the effectiveness of colistin, posing a substantial threat to public health. Although several key plasmid elements that balance mcr‐1 persistence and bacterial growth are identified, the regulatory interactions between mcr‐1 and h...

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Bibliographic Details
Main Authors: Haijie Zhang, Xia Xiao, Chenlong Wang, Yurong Zhao, Bo Chen, Xinyuan Ji, Lina Gu, Jie Wang, Zhiqiang Wang, Yuan Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
bacteria
colistin resistance
dinB
fitness cost
mcr expression
Online Access:https://doi.org/10.1002/advs.202411994
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