Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans
Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/730920 |
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| author | A. P. Doumatey J. Zhou H. Huang J. Adeleye W. Balogun O. Fasanmade T. Johnson J. Oli G. Okafor A. Amoah B. Eghan K. Agyenim-Boateng J. Acheampong C. Adebamowo A. Adeyemo C. N. Rotimi |
| author_facet | A. P. Doumatey J. Zhou H. Huang J. Adeleye W. Balogun O. Fasanmade T. Johnson J. Oli G. Okafor A. Amoah B. Eghan K. Agyenim-Boateng J. Acheampong C. Adebamowo A. Adeyemo C. N. Rotimi |
| author_sort | A. P. Doumatey |
| collection | DOAJ |
| description | Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans.
Total adiponectin was measured in 792 participants. MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function. Linear and logistic regression models were used to determine the relationship between adiponectin and renal function.
Adiponectin showed an inverse relationship with eGFR in univariate (BetaMDRD=-0.18, BetaCG=-0.26) and multivariate (BetaMDRD=-0.10, BetaCG=-0.09) regression analyses. The multivariate models that included age, sex, BMI, hypertension, smoking, HDL-C, LDL-C, triglycerides, and adiponectin explained 30% and 55.6% of the variance in GFR estimated by MDRD and CG methods, respectively. Adiponectin was also a strong predictor of moderate chronic kidney disease (defined as eGFR < 60 mL/min/1.73 m2). We demonstrate that adiponectin is associated with renal function in nondiabetic West Africans. The observed relationship is independent of age and serum lipids. Our findings suggest that adiponectin may have clinical utility as a biomarker of renal function. |
| format | Article |
| id | doaj-art-73fafb32892b4ff68eae709e6d2b0b54 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-73fafb32892b4ff68eae709e6d2b0b542025-08-20T03:33:54ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/730920730920Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West AfricansA. P. Doumatey0J. Zhou1H. Huang2J. Adeleye3W. Balogun4O. Fasanmade5T. Johnson6J. Oli7G. Okafor8A. Amoah9B. Eghan10K. Agyenim-Boateng11J. Acheampong12C. Adebamowo13A. Adeyemo14C. N. Rotimi15Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USACenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USACenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USADepartment of Medicine, University of Ibadan, Ibadan 200284, NigeriaDepartment of Medicine, University of Ibadan, Ibadan 200284, NigeriaDepartment of Medicine, University of Lagos, Lagos 101017, NigeriaDepartment of Medicine, University of Lagos, Lagos 101017, NigeriaDepartment of Medicine, University of Nigeria Teaching Hospital, Enugu 400001, NigeriaDepartment of Medicine, University of Nigeria Teaching Hospital, Enugu 400001, NigeriaDepartment of Medicine and Therapeutics, University of Ghana Medical School, Accra, GhanaDepartment of Medicine, University of Science and Technology, Kumasi, GhanaDepartment of Medicine, University of Science and Technology, Kumasi, GhanaDepartment of Medicine, University of Science and Technology, Kumasi, GhanaDepartment of Medicine, University of Ibadan, Ibadan 200284, NigeriaCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USACenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USAAdiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans. Total adiponectin was measured in 792 participants. MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function. Linear and logistic regression models were used to determine the relationship between adiponectin and renal function. Adiponectin showed an inverse relationship with eGFR in univariate (BetaMDRD=-0.18, BetaCG=-0.26) and multivariate (BetaMDRD=-0.10, BetaCG=-0.09) regression analyses. The multivariate models that included age, sex, BMI, hypertension, smoking, HDL-C, LDL-C, triglycerides, and adiponectin explained 30% and 55.6% of the variance in GFR estimated by MDRD and CG methods, respectively. Adiponectin was also a strong predictor of moderate chronic kidney disease (defined as eGFR < 60 mL/min/1.73 m2). We demonstrate that adiponectin is associated with renal function in nondiabetic West Africans. The observed relationship is independent of age and serum lipids. Our findings suggest that adiponectin may have clinical utility as a biomarker of renal function.http://dx.doi.org/10.1155/2012/730920 |
| spellingShingle | A. P. Doumatey J. Zhou H. Huang J. Adeleye W. Balogun O. Fasanmade T. Johnson J. Oli G. Okafor A. Amoah B. Eghan K. Agyenim-Boateng J. Acheampong C. Adebamowo A. Adeyemo C. N. Rotimi Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans International Journal of Nephrology |
| title | Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans |
| title_full | Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans |
| title_fullStr | Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans |
| title_full_unstemmed | Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans |
| title_short | Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans |
| title_sort | circulating adiponectin is associated with renal function independent of age and serum lipids in west africans |
| url | http://dx.doi.org/10.1155/2012/730920 |
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