Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System
We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Optics |
| Online Access: | http://dx.doi.org/10.1155/2012/276367 |
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| Summary: | We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the combination of a CCD camera and DCA can significantly improve the accuracy in depth localization and lead to reconstruction of 3D volumetric images. This approach may present great interests for noninvasive 3D localization of an anomaly hidden in tissue, such as a tumor or a stroke lesion, for preclinical small animal models. |
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| ISSN: | 1687-9384 1687-9392 |