Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis
Background There is no strong evidence demonstrating whether or not aerobic exercise in conjunction with resistance exercise improves metabolic diabetes markers in postmenopausal women.Objective To evaluate the effect of aerobic exercise and resistance training on metabolic markers in postmenopausal...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2450338 |
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| author | Vitor Engracia Valenti André dos Santos Chagas Peter Chedraui Ingrid Soares de Souza Andrey Alves Porto Isabel Cristina Esposito Sorpreso Jose Maria Soares Júnior Juliana Zangirolami-Raimundo David M. Garner Rodrigo Daminello Raimundo |
| author_facet | Vitor Engracia Valenti André dos Santos Chagas Peter Chedraui Ingrid Soares de Souza Andrey Alves Porto Isabel Cristina Esposito Sorpreso Jose Maria Soares Júnior Juliana Zangirolami-Raimundo David M. Garner Rodrigo Daminello Raimundo |
| author_sort | Vitor Engracia Valenti |
| collection | DOAJ |
| description | Background There is no strong evidence demonstrating whether or not aerobic exercise in conjunction with resistance exercise improves metabolic diabetes markers in postmenopausal women.Objective To evaluate the effect of aerobic exercise and resistance training on metabolic markers in postmenopausal women with type 2 diabetes mellitus (T2DM) by means of a systematic review and meta-analysis.Methods The searches were completed using EMBASE, MEDLINE/PubMed, Scopus and Web of Science databases. This study included non-blinded, single or double-blinded randomized control trials and postmenopausal women diagnosed with T2DM. The imposed intervention was aerobic exercise plus any training protocol to strengthen muscle groups for resistance intervention. The outcomes of interest were the blood glucose levels, insulin secretion, homeostasis model assessment-insulin resistance index (HOMA-IR) and glycated hemoglobin (HbA1c). Risk of Bias tools and GRADE were obligatory.Results Three studies were included (83 participants). Exercise intervention ranged between two to four days per week. Compared to the control group, in the group submitted to aerobic exercise + resistance training, no significant change was noted for HbA1c (subtotal = mean difference − 0.35 [95% CI: −0.85, 0.15], p = .17, and heterogeneity = 0%) (GRADE: very low), nevertheless, HOMA-IR index was significantly improved (subtotal = mean difference −0.52 [95% CI: −0.99, −0.05], p = .03, and heterogeneity = 0%) (GRADE: very low).Conclusion Despite the very low certainty found in the quality of evidences, our analysis showed that aerobic exercise along with strength exercise seems to improve some metabolic diabetes markers in postmenopausal women with T2DM. There is a need for further studies to support our preliminary findings. |
| format | Article |
| id | doaj-art-73f61a0235dc49e8a91379bea0555cc3 |
| institution | Kabale University |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-73f61a0235dc49e8a91379bea0555cc32025-01-11T10:44:42ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2450338Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysisVitor Engracia Valenti0André dos Santos Chagas1Peter Chedraui2Ingrid Soares de Souza3Andrey Alves Porto4Isabel Cristina Esposito Sorpreso5Jose Maria Soares Júnior6Juliana Zangirolami-Raimundo7David M. Garner8Rodrigo Daminello Raimundo9Autonomic Nervous System Center, Sao Paulo State University, UNESP, Marília, SP, BrazilAutonomic Nervous System Center, Sao Paulo State University, UNESP, Marília, SP, BrazilEscuela de Postgrado en Salud, Universidad Espíritu Santo, Samborondón, EcuadorCentro Universitário Faculdade de Medicina do ABC (FMABC), São Paulo, Santo André, BrazilAutonomic Nervous System Center, Sao Paulo State University, UNESP, Marília, SP, BrazilLaboratory for Medical Research in Structural and Molecular Gynecology, Discipline of Gynecology, Department of Gynecology and Obstetrics, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, BrazilLaboratory for Medical Research in Structural and Molecular Gynecology, Discipline of Gynecology, Department of Gynecology and Obstetrics, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, BrazilCentro Universitário Faculdade de Medicina do ABC (FMABC), São Paulo, Santo André, BrazilCardiorespiratory Research Group, Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UKCentro Universitário Faculdade de Medicina do ABC (FMABC), São Paulo, Santo André, BrazilBackground There is no strong evidence demonstrating whether or not aerobic exercise in conjunction with resistance exercise improves metabolic diabetes markers in postmenopausal women.Objective To evaluate the effect of aerobic exercise and resistance training on metabolic markers in postmenopausal women with type 2 diabetes mellitus (T2DM) by means of a systematic review and meta-analysis.Methods The searches were completed using EMBASE, MEDLINE/PubMed, Scopus and Web of Science databases. This study included non-blinded, single or double-blinded randomized control trials and postmenopausal women diagnosed with T2DM. The imposed intervention was aerobic exercise plus any training protocol to strengthen muscle groups for resistance intervention. The outcomes of interest were the blood glucose levels, insulin secretion, homeostasis model assessment-insulin resistance index (HOMA-IR) and glycated hemoglobin (HbA1c). Risk of Bias tools and GRADE were obligatory.Results Three studies were included (83 participants). Exercise intervention ranged between two to four days per week. Compared to the control group, in the group submitted to aerobic exercise + resistance training, no significant change was noted for HbA1c (subtotal = mean difference − 0.35 [95% CI: −0.85, 0.15], p = .17, and heterogeneity = 0%) (GRADE: very low), nevertheless, HOMA-IR index was significantly improved (subtotal = mean difference −0.52 [95% CI: −0.99, −0.05], p = .03, and heterogeneity = 0%) (GRADE: very low).Conclusion Despite the very low certainty found in the quality of evidences, our analysis showed that aerobic exercise along with strength exercise seems to improve some metabolic diabetes markers in postmenopausal women with T2DM. There is a need for further studies to support our preliminary findings.https://www.tandfonline.com/doi/10.1080/09513590.2025.2450338Aerobic exercisediabetesexerciseresistance trainingpostmenopause |
| spellingShingle | Vitor Engracia Valenti André dos Santos Chagas Peter Chedraui Ingrid Soares de Souza Andrey Alves Porto Isabel Cristina Esposito Sorpreso Jose Maria Soares Júnior Juliana Zangirolami-Raimundo David M. Garner Rodrigo Daminello Raimundo Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis Gynecological Endocrinology Aerobic exercise diabetes exercise resistance training postmenopause |
| title | Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis |
| title_full | Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis |
| title_fullStr | Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis |
| title_short | Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis |
| title_sort | effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes a systematic review and meta analysis |
| topic | Aerobic exercise diabetes exercise resistance training postmenopause |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2450338 |
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