Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total‐body irradiation or treosulfan‐based conditioning regimens

Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total‐body irradiation or treosulfan‐based conditioning regimens

Abstract Background Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and...

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Bibliographic Details
Main Authors: Yuji Tanaka, Tetsuro Hanada, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Shunichiro Tsuji, Takashi Murakami
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Reproductive Medicine and Biology
Subjects:
fertility preservation
hematopoietic stem cell transplant
ovarian shielding
pediatric patients
treosulfan
Online Access:https://doi.org/10.1002/rmb2.12648
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