Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh
Abstract Rapid economic development and urbanization have significantly increased PM2.5-induced and hyperglycemia-induced toxicological effects. Tempeh is a traditional Indonesian food and may be beneficial for patients with type II diabetes. However, the toxicological effects of co-exposure to traf...
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| Format: | Article |
| Language: | English |
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Springer
2022-12-01
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| Series: | Aerosol and Air Quality Research |
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| Online Access: | https://doi.org/10.4209/aaqr.220340 |
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| author | Jian-He Lu Ming-Hsien Tsai Sen-Ting Huang Jia-De Lee Ta-Chih Hsiao Wan Nurdiyana Wan Mansor How-Ran Chao |
| author_facet | Jian-He Lu Ming-Hsien Tsai Sen-Ting Huang Jia-De Lee Ta-Chih Hsiao Wan Nurdiyana Wan Mansor How-Ran Chao |
| author_sort | Jian-He Lu |
| collection | DOAJ |
| description | Abstract Rapid economic development and urbanization have significantly increased PM2.5-induced and hyperglycemia-induced toxicological effects. Tempeh is a traditional Indonesian food and may be beneficial for patients with type II diabetes. However, the toxicological effects of co-exposure to traffic-related-air-pollutant (TRAP) PM2.5 with high glucose and the potential therapeutic effect of tempeh remain unclear. Using Caenorhabditis elegans (C. elegans) as an in vivo animal model, we found that exposure to 12.74 mg L−1 TRAP PM2.5 and 80 mM D-glucose could induce toxicity in nematodes that affects growth, reproduction, locomotion behavior, and lifespan. Moreover, TRAP PM2.5 and high glucose diet co-treatment reinforced these adverse effects on C. elegans. However, pretreatment with 200 µg of tempeh extract had the greatest improvement in the adverse effects of treatment with or without 12.74 mg L−1 TRAP PM2.5 and with or without 80 mM D-glucose on C. elegans. In addition, tempeh treatment also ameliorated the altered mRNA expression of the antioxidant gene in C. elegans treated with or without TRAP PM2.5 and with or without high-dose glucose diets. These findings reveal that co-exposure to TRAP PM2.5 and high-dose glucose causes more serious health effects, while tempeh could modulate oxidative stress which ameliorated TRAP PM2.5-induced and hyperglycemia-induced toxicological effects. |
| format | Article |
| id | doaj-art-73e0c39152ab44e98e9183cfbd93e0b3 |
| institution | Kabale University |
| issn | 1680-8584 2071-1409 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Aerosol and Air Quality Research |
| spelling | doaj-art-73e0c39152ab44e98e9183cfbd93e0b32025-02-09T12:23:27ZengSpringerAerosol and Air Quality Research1680-85842071-14092022-12-0123212110.4209/aaqr.220340Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and TempehJian-He Lu0Ming-Hsien Tsai1Sen-Ting Huang2Jia-De Lee3Ta-Chih Hsiao4Wan Nurdiyana Wan Mansor5How-Ran Chao6Emerging Compounds Research Center, General Research Service Center, National Pingtung University of Science and TechnologyDepartment of Child Care, College of Humanities and Social Sciences, National Pingtung University of Science and TechnologyDepartment of Environmental Science and Engineering, National Pingtung University of Science and TechnologyDepartment of Environmental Science and Engineering, National Pingtung University of Science and TechnologyGraduate Institute of Environmental Engineering, National Taiwan UniversityFaculty of Ocean Engineering Technology & Informatics, Universiti Malaysia TerengganuEmerging Compounds Research Center, General Research Service Center, National Pingtung University of Science and TechnologyAbstract Rapid economic development and urbanization have significantly increased PM2.5-induced and hyperglycemia-induced toxicological effects. Tempeh is a traditional Indonesian food and may be beneficial for patients with type II diabetes. However, the toxicological effects of co-exposure to traffic-related-air-pollutant (TRAP) PM2.5 with high glucose and the potential therapeutic effect of tempeh remain unclear. Using Caenorhabditis elegans (C. elegans) as an in vivo animal model, we found that exposure to 12.74 mg L−1 TRAP PM2.5 and 80 mM D-glucose could induce toxicity in nematodes that affects growth, reproduction, locomotion behavior, and lifespan. Moreover, TRAP PM2.5 and high glucose diet co-treatment reinforced these adverse effects on C. elegans. However, pretreatment with 200 µg of tempeh extract had the greatest improvement in the adverse effects of treatment with or without 12.74 mg L−1 TRAP PM2.5 and with or without 80 mM D-glucose on C. elegans. In addition, tempeh treatment also ameliorated the altered mRNA expression of the antioxidant gene in C. elegans treated with or without TRAP PM2.5 and with or without high-dose glucose diets. These findings reveal that co-exposure to TRAP PM2.5 and high-dose glucose causes more serious health effects, while tempeh could modulate oxidative stress which ameliorated TRAP PM2.5-induced and hyperglycemia-induced toxicological effects.https://doi.org/10.4209/aaqr.220340Particulate matterHigh-dose glucoseTempehCaenorhabditis elegans |
| spellingShingle | Jian-He Lu Ming-Hsien Tsai Sen-Ting Huang Jia-De Lee Ta-Chih Hsiao Wan Nurdiyana Wan Mansor How-Ran Chao Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh Aerosol and Air Quality Research Particulate matter High-dose glucose Tempeh Caenorhabditis elegans |
| title | Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh |
| title_full | Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh |
| title_fullStr | Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh |
| title_full_unstemmed | Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh |
| title_short | Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh |
| title_sort | traffic related air pollutant pm2 5 caused toxicity on caenorhabditis elegans with cotreatment of high dose glucose and tempeh |
| topic | Particulate matter High-dose glucose Tempeh Caenorhabditis elegans |
| url | https://doi.org/10.4209/aaqr.220340 |
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