Research progress of implantable materials in antibacterial treatment of bone infection
Bone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial material...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1586898/full |
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| author | Binqing Xiang Jingui Jiang Heng Wang Lei Song |
| author_facet | Binqing Xiang Jingui Jiang Heng Wang Lei Song |
| author_sort | Binqing Xiang |
| collection | DOAJ |
| description | Bone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial materials, highlighting their essential role in clinical treatment. In this review, we systematically analyze research progress in antibacterial implant materials for Bone infection from 2019 to 2025. Materials are classified into four categories based on matrix composition: metal-based composite implants, bioceramic-based composite implants, polymer-based composite implants, and other composite implant materials, with dedicated focus on the limitations of each material type. The deterioration effects of these materials are also thoroughly analyzed. Finally, we present our own insights regarding future development directions of antibacterial implant materials. This review aims to provide practical references and research perspectives for advancing antibacterial implant material development. |
| format | Article |
| id | doaj-art-73df7d649eb74256b15eac1216c9db2d |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-73df7d649eb74256b15eac1216c9db2d2025-08-20T03:30:27ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.15868981586898Research progress of implantable materials in antibacterial treatment of bone infectionBinqing Xiang0Jingui Jiang1Heng Wang2Lei Song3Department of Surgical Anesthesia, First Affiliated Hospital, Army Medical University, Chongqing, ChinaBasic Medical College, Army Medical University, Chongqing, ChinaFirst Affiliated Hospital, Army Medical University, Chongqing, ChinaDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, ChinaBone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial materials, highlighting their essential role in clinical treatment. In this review, we systematically analyze research progress in antibacterial implant materials for Bone infection from 2019 to 2025. Materials are classified into four categories based on matrix composition: metal-based composite implants, bioceramic-based composite implants, polymer-based composite implants, and other composite implant materials, with dedicated focus on the limitations of each material type. The deterioration effects of these materials are also thoroughly analyzed. Finally, we present our own insights regarding future development directions of antibacterial implant materials. This review aims to provide practical references and research perspectives for advancing antibacterial implant material development.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1586898/fullbone infectionimplantable materialsantibacterial treatmentcomposite materialsmaterial matrix |
| spellingShingle | Binqing Xiang Jingui Jiang Heng Wang Lei Song Research progress of implantable materials in antibacterial treatment of bone infection Frontiers in Bioengineering and Biotechnology bone infection implantable materials antibacterial treatment composite materials material matrix |
| title | Research progress of implantable materials in antibacterial treatment of bone infection |
| title_full | Research progress of implantable materials in antibacterial treatment of bone infection |
| title_fullStr | Research progress of implantable materials in antibacterial treatment of bone infection |
| title_full_unstemmed | Research progress of implantable materials in antibacterial treatment of bone infection |
| title_short | Research progress of implantable materials in antibacterial treatment of bone infection |
| title_sort | research progress of implantable materials in antibacterial treatment of bone infection |
| topic | bone infection implantable materials antibacterial treatment composite materials material matrix |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1586898/full |
| work_keys_str_mv | AT binqingxiang researchprogressofimplantablematerialsinantibacterialtreatmentofboneinfection AT jinguijiang researchprogressofimplantablematerialsinantibacterialtreatmentofboneinfection AT hengwang researchprogressofimplantablematerialsinantibacterialtreatmentofboneinfection AT leisong researchprogressofimplantablematerialsinantibacterialtreatmentofboneinfection |