Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis

Dermatomyositis (DM) is an autoimmune inflammatory myopathy with heterogeneous systemic and cutaneous manifestations. Certain forms of DM have isolated skin findings without overt myositis and are called amyopathic DM. Myositis-specific autoantibodies are associated with distinct phenotypes of DM th...

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Main Authors: Gayane Matusov, Toan Do, Richard Keating, Geva Mannor, Andrew White
Format: Article
Language:English
Published: American College of Physicians 2025-07-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2025.0236
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author Gayane Matusov
Toan Do
Richard Keating
Geva Mannor
Andrew White
author_facet Gayane Matusov
Toan Do
Richard Keating
Geva Mannor
Andrew White
author_sort Gayane Matusov
collection DOAJ
description Dermatomyositis (DM) is an autoimmune inflammatory myopathy with heterogeneous systemic and cutaneous manifestations. Certain forms of DM have isolated skin findings without overt myositis and are called amyopathic DM. Myositis-specific autoantibodies are associated with distinct phenotypes of DM that can support the diagnosis and better define management and prognostication. We describe a case of amyopathic DM with the presence of the small ubiquitin-like modifier activation enzyme 1 autoantibody presenting with severe, debilitating periorbital edema.
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institution Kabale University
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publisher American College of Physicians
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series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-73df20063b604f5787f00e722a5a95f92025-08-20T03:32:57ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-07-014710.7326/aimcc.2025.0236Debilitating Periorbital Edema Secondary to Anti-SAE DermatomyositisGayane Matusov0Toan Do1Richard Keating2Geva Mannor3Andrew White41Department of Internal Medicine, Scripps Green Hospital, La Jolla, California3Division of Allergy & Immunology, Department of Medicine, University of California San Diego, San Diego, California4Division of Rheumatology, Division of Allergy, Asthma & Immunology, Scripps Clinic Medical Group, La Jolla, California5Division of Ophthalmology, Department of Surgery, Scripps Clinic, San Diego, California6Division of Allergy, Asthma & Immunology, Scripps Clinic Medical Group, La Jolla, CaliforniaDermatomyositis (DM) is an autoimmune inflammatory myopathy with heterogeneous systemic and cutaneous manifestations. Certain forms of DM have isolated skin findings without overt myositis and are called amyopathic DM. Myositis-specific autoantibodies are associated with distinct phenotypes of DM that can support the diagnosis and better define management and prognostication. We describe a case of amyopathic DM with the presence of the small ubiquitin-like modifier activation enzyme 1 autoantibody presenting with severe, debilitating periorbital edema.https://www.acpjournals.org/doi/10.7326/aimcc.2025.0236
spellingShingle Gayane Matusov
Toan Do
Richard Keating
Geva Mannor
Andrew White
Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
Annals of Internal Medicine: Clinical Cases
title Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
title_full Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
title_fullStr Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
title_full_unstemmed Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
title_short Debilitating Periorbital Edema Secondary to Anti-SAE Dermatomyositis
title_sort debilitating periorbital edema secondary to anti sae dermatomyositis
url https://www.acpjournals.org/doi/10.7326/aimcc.2025.0236
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