Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment
Metabolomics research provides a clearer understanding of an organism’s metabolic state and enables a more accurate representation of its functional performance. This study aimed to investigate changes in the metabolome of lung tissues resulting from prenatal exposure to polystyrene microplastics (P...
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MDPI AG
2024-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/12/1459 |
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| author | Hong-Ren Yu Ching-Yi Tsai Wei-Ling Chen Po-Yu Liu You-Lin Tain Jiunn-Ming Sheen Yi-Siang Huang Mao-Meng Tiao Chih-Yung Chiu |
| author_facet | Hong-Ren Yu Ching-Yi Tsai Wei-Ling Chen Po-Yu Liu You-Lin Tain Jiunn-Ming Sheen Yi-Siang Huang Mao-Meng Tiao Chih-Yung Chiu |
| author_sort | Hong-Ren Yu |
| collection | DOAJ |
| description | Metabolomics research provides a clearer understanding of an organism’s metabolic state and enables a more accurate representation of its functional performance. This study aimed to investigate changes in the metabolome of lung tissues resulting from prenatal exposure to polystyrene microplastics (PS-MPs) and to understand the underlying mechanisms of lung damage in rat offspring. We conducted metabolomic analyses of lung tissue from seven-day-old rat pups exposed to prenatal PS-MPs. Our findings revealed that prenatal exposure to PS-MPs led to significantly increased oxidative stress in lung tissues, characterized by notable imbalances in nucleic acid metabolism and altered profiles of specific amino acids. Furthermore, we evaluated the therapeutic effects of melatonin treatment on lung function in 120-day-old offspring and found that melatonin treatment significantly improved lung function and histologic change in the affected offspring. This study provides valuable biological insights into the mechanisms underlying lung damage caused by prenatal PS-MPs exposure. Future studies should focus on validating the results of animal experiments in humans, exploring additional therapeutic mechanisms of melatonin, and developing suitable protocols for clinical use. |
| format | Article |
| id | doaj-art-73d67666410b4487a58a4b4263626aba |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-73d67666410b4487a58a4b4263626aba2025-08-20T02:50:56ZengMDPI AGAntioxidants2076-39212024-11-011312145910.3390/antiox13121459Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin TreatmentHong-Ren Yu0Ching-Yi Tsai1Wei-Ling Chen2Po-Yu Liu3You-Lin Tain4Jiunn-Ming Sheen5Yi-Siang Huang6Mao-Meng Tiao7Chih-Yung Chiu8Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanInstitute for Translational Research in Biomedicine, Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanSchool of Medicine, College of Medicine, The Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung 807, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan 333, TaiwanMetabolomics research provides a clearer understanding of an organism’s metabolic state and enables a more accurate representation of its functional performance. This study aimed to investigate changes in the metabolome of lung tissues resulting from prenatal exposure to polystyrene microplastics (PS-MPs) and to understand the underlying mechanisms of lung damage in rat offspring. We conducted metabolomic analyses of lung tissue from seven-day-old rat pups exposed to prenatal PS-MPs. Our findings revealed that prenatal exposure to PS-MPs led to significantly increased oxidative stress in lung tissues, characterized by notable imbalances in nucleic acid metabolism and altered profiles of specific amino acids. Furthermore, we evaluated the therapeutic effects of melatonin treatment on lung function in 120-day-old offspring and found that melatonin treatment significantly improved lung function and histologic change in the affected offspring. This study provides valuable biological insights into the mechanisms underlying lung damage caused by prenatal PS-MPs exposure. Future studies should focus on validating the results of animal experiments in humans, exploring additional therapeutic mechanisms of melatonin, and developing suitable protocols for clinical use.https://www.mdpi.com/2076-3921/13/12/1459microplasticsoffspringlungmetabolomeoxidative stressmelatonin |
| spellingShingle | Hong-Ren Yu Ching-Yi Tsai Wei-Ling Chen Po-Yu Liu You-Lin Tain Jiunn-Ming Sheen Yi-Siang Huang Mao-Meng Tiao Chih-Yung Chiu Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment Antioxidants microplastics offspring lung metabolome oxidative stress melatonin |
| title | Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment |
| title_full | Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment |
| title_fullStr | Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment |
| title_full_unstemmed | Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment |
| title_short | Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment |
| title_sort | exploring oxidative stress and metabolic dysregulation in lung tissues of offspring rats exposed to prenatal polystyrene microplastics effects of melatonin treatment |
| topic | microplastics offspring lung metabolome oxidative stress melatonin |
| url | https://www.mdpi.com/2076-3921/13/12/1459 |
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