In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice
Background. Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. Carica papaya is used traditionally and showed in vitro antimalarial activity. This study attempted to evaluate in vivo antimalarial activity of C. papaya in mice....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3121050 |
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| author | Gemechu Zeleke Dereje Kebebe Eshetu Mulisa Fanta Gashe |
| author_facet | Gemechu Zeleke Dereje Kebebe Eshetu Mulisa Fanta Gashe |
| author_sort | Gemechu Zeleke |
| collection | DOAJ |
| description | Background. Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. Carica papaya is used traditionally and showed in vitro antimalarial activity. This study attempted to evaluate in vivo antimalarial activity of C. papaya in mice. Methods. In vivo antimalarial activity of solvent fractions of the plant was carried out against early P. berghei infection in mice. Parasitemia, temperature, PCV, and body weight of mice were recorded. Windows SPSS version 16 (one-way ANOVA followed by Tukey’s post hoc test) was used for data analysis. Results. The pet ether and chloroform fractions of C. papaya fruit rind and root produced a significant (p<0.001) chemosuppressive effect. A maximum parasite suppression of 61.78% was produced by pet ether fraction of C. papaya fruit rind in the highest dose (400 mg/kg/day). Only 400 mg/kg/day dose of chloroform fraction of C. papaya root exhibited a parasite suppression effect (48.11%). But, methanol fraction of the plant parts produced less chemosuppressive effect. Conclusion. Pet ether fraction of C. papaya fruit rind had the highest antimalarial activity and could be a potential source of lead compound. Further study should be done to show the chemical and metabolomic profile of active ingredients. |
| format | Article |
| id | doaj-art-73d5ac6082f04939abdab14d79e0ff57 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-73d5ac6082f04939abdab14d79e0ff572025-08-20T03:33:53ZengWileyJournal of Parasitology Research2090-00232090-00312017-01-01201710.1155/2017/31210503121050In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in MiceGemechu Zeleke0Dereje Kebebe1Eshetu Mulisa2Fanta Gashe3Pharmacology Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, EthiopiaPharmaceutics Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, EthiopiaPharmacology Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, EthiopiaPharmaceutics Course Team, School of Pharmacy, Jimma University, P.O. Box 378, Jimma, EthiopiaBackground. Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. Carica papaya is used traditionally and showed in vitro antimalarial activity. This study attempted to evaluate in vivo antimalarial activity of C. papaya in mice. Methods. In vivo antimalarial activity of solvent fractions of the plant was carried out against early P. berghei infection in mice. Parasitemia, temperature, PCV, and body weight of mice were recorded. Windows SPSS version 16 (one-way ANOVA followed by Tukey’s post hoc test) was used for data analysis. Results. The pet ether and chloroform fractions of C. papaya fruit rind and root produced a significant (p<0.001) chemosuppressive effect. A maximum parasite suppression of 61.78% was produced by pet ether fraction of C. papaya fruit rind in the highest dose (400 mg/kg/day). Only 400 mg/kg/day dose of chloroform fraction of C. papaya root exhibited a parasite suppression effect (48.11%). But, methanol fraction of the plant parts produced less chemosuppressive effect. Conclusion. Pet ether fraction of C. papaya fruit rind had the highest antimalarial activity and could be a potential source of lead compound. Further study should be done to show the chemical and metabolomic profile of active ingredients.http://dx.doi.org/10.1155/2017/3121050 |
| spellingShingle | Gemechu Zeleke Dereje Kebebe Eshetu Mulisa Fanta Gashe In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice Journal of Parasitology Research |
| title | In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice |
| title_full | In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice |
| title_fullStr | In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice |
| title_full_unstemmed | In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice |
| title_short | In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice |
| title_sort | in vivo antimalarial activity of the solvent fractions of fruit rind and root of carica papaya linn caricaceae against plasmodium berghei in mice |
| url | http://dx.doi.org/10.1155/2017/3121050 |
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