Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024.
<h4>Background</h4>In Mexico, some of the most prevalent noncommunicable diseases (NCDs) among adults are diabetes, hypertension, and chronic kidney disease (CKD). Mexico is currently facing a syndemic characterized by the convergence of dengue and NCDs. This study aims to describe and a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-07-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0012933 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396844949405696 |
|---|---|
| author | Diego Rolando Hernández-Galdamez Miguel Ángel González-Block Daniela Karola Romo-Dueñas Erick Antonio Osorio-López Rosalba Cerón-Meza Pablo Méndez-Hernández |
| author_facet | Diego Rolando Hernández-Galdamez Miguel Ángel González-Block Daniela Karola Romo-Dueñas Erick Antonio Osorio-López Rosalba Cerón-Meza Pablo Méndez-Hernández |
| author_sort | Diego Rolando Hernández-Galdamez |
| collection | DOAJ |
| description | <h4>Background</h4>In Mexico, some of the most prevalent noncommunicable diseases (NCDs) among adults are diabetes, hypertension, and chronic kidney disease (CKD). Mexico is currently facing a syndemic characterized by the convergence of dengue and NCDs. This study aims to describe and analyze the association between the prevalence of NCDs and hospitalization, the presence of hemorrhagic disorders, and death in all officially confirmed cases of dengue in Mexico during 2024.<h4>Methodology/principal findings</h4>This cross-sectional study was carried out through a secondary analysis of the confirmed cases of dengue reported in 2024. We assessed the associations between NCDs and the probability of hospitalization, bleeding disorders, and death, using one logistic regression model for each clinical outcome. We adjusted the three models for age, sex, social security affiliation, ethnicity and for each of the NCDs (diabetes, hypertension, chronic kidney disease, immunosuppression, cirrhosis, and peptic ulcer disease). The most common noncommunicable diseases were diabetes, hypertension, CKD, and immunosuppression. For hospitalization, CKD had the strongest association (OR 5.74), followed by immunosuppression (OR 2.84), peptic ulcer disease (OR 2.33), and diabetes (OR 2.10). We found significant associations between bleeding disorders and several NCDs (diabetes, peptic ulcer disease, immunosuppression, cirrhosis, and hypertension) compared to people without these conditions. People with CKD, peptic ulcer disease and diabetes, had more odds for death compared to those without these comorbidities.<h4>Conclusions/significance</h4>We found a significant association between several comorbidities and worse clinical outcomes in patients with dengue, such as hospitalization, bleeding disorders, or death. The syndemic of NCDs and dengue in Mexico has been rapidly increasing, and this problem needs to be addressed. This work confirms and extends the findings of previous studies and suggests that patients with these comorbidities have worse clinical outcomes. |
| format | Article |
| id | doaj-art-73d2f0613fbf47a9a9cb52338e8b4eef |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-73d2f0613fbf47a9a9cb52338e8b4eef2025-08-20T03:39:14ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-07-01197e001293310.1371/journal.pntd.0012933Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024.Diego Rolando Hernández-GaldamezMiguel Ángel González-BlockDaniela Karola Romo-DueñasErick Antonio Osorio-LópezRosalba Cerón-MezaPablo Méndez-Hernández<h4>Background</h4>In Mexico, some of the most prevalent noncommunicable diseases (NCDs) among adults are diabetes, hypertension, and chronic kidney disease (CKD). Mexico is currently facing a syndemic characterized by the convergence of dengue and NCDs. This study aims to describe and analyze the association between the prevalence of NCDs and hospitalization, the presence of hemorrhagic disorders, and death in all officially confirmed cases of dengue in Mexico during 2024.<h4>Methodology/principal findings</h4>This cross-sectional study was carried out through a secondary analysis of the confirmed cases of dengue reported in 2024. We assessed the associations between NCDs and the probability of hospitalization, bleeding disorders, and death, using one logistic regression model for each clinical outcome. We adjusted the three models for age, sex, social security affiliation, ethnicity and for each of the NCDs (diabetes, hypertension, chronic kidney disease, immunosuppression, cirrhosis, and peptic ulcer disease). The most common noncommunicable diseases were diabetes, hypertension, CKD, and immunosuppression. For hospitalization, CKD had the strongest association (OR 5.74), followed by immunosuppression (OR 2.84), peptic ulcer disease (OR 2.33), and diabetes (OR 2.10). We found significant associations between bleeding disorders and several NCDs (diabetes, peptic ulcer disease, immunosuppression, cirrhosis, and hypertension) compared to people without these conditions. People with CKD, peptic ulcer disease and diabetes, had more odds for death compared to those without these comorbidities.<h4>Conclusions/significance</h4>We found a significant association between several comorbidities and worse clinical outcomes in patients with dengue, such as hospitalization, bleeding disorders, or death. The syndemic of NCDs and dengue in Mexico has been rapidly increasing, and this problem needs to be addressed. This work confirms and extends the findings of previous studies and suggests that patients with these comorbidities have worse clinical outcomes.https://doi.org/10.1371/journal.pntd.0012933 |
| spellingShingle | Diego Rolando Hernández-Galdamez Miguel Ángel González-Block Daniela Karola Romo-Dueñas Erick Antonio Osorio-López Rosalba Cerón-Meza Pablo Méndez-Hernández Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. PLoS Neglected Tropical Diseases |
| title | Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. |
| title_full | Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. |
| title_fullStr | Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. |
| title_full_unstemmed | Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. |
| title_short | Noncommunicable diseases associated with bleeding disorders, hospitalization, and mortality in patients with dengue in Mexico: A national analysis of confirmed cases in 2024. |
| title_sort | noncommunicable diseases associated with bleeding disorders hospitalization and mortality in patients with dengue in mexico a national analysis of confirmed cases in 2024 |
| url | https://doi.org/10.1371/journal.pntd.0012933 |
| work_keys_str_mv | AT diegorolandohernandezgaldamez noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 AT miguelangelgonzalezblock noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 AT danielakarolaromoduenas noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 AT erickantonioosoriolopez noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 AT rosalbaceronmeza noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 AT pablomendezhernandez noncommunicablediseasesassociatedwithbleedingdisordershospitalizationandmortalityinpatientswithdengueinmexicoanationalanalysisofconfirmedcasesin2024 |