Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020.
<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) greatly influence morbidity and mortality, with COPD patients frequently suffering from cardiovascular comorbidities like coronary heart disease and stroke. This study analyzes mortality tren...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317592 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864087435542528 |
|---|---|
| author | Aman Goyal Humza Saeed Wania Sultan Ajeet Singh Abdullah Muhammad Khubaib Arshad Zubair Amin Mah I Kan Changez Gauranga Mahalwar Rozi Khan Wael AlJaroudi |
| author_facet | Aman Goyal Humza Saeed Wania Sultan Ajeet Singh Abdullah Muhammad Khubaib Arshad Zubair Amin Mah I Kan Changez Gauranga Mahalwar Rozi Khan Wael AlJaroudi |
| author_sort | Aman Goyal |
| collection | DOAJ |
| description | <h4>Background</h4>Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) greatly influence morbidity and mortality, with COPD patients frequently suffering from cardiovascular comorbidities like coronary heart disease and stroke. This study analyzes mortality trends and disparities among individuals in the United States (US) affected by both CVD and COPD.<h4>Methods</h4>This study analyzed death certificates from the CDC WONDER database for individuals aged 25 and older who died between 1999 and 2020 with both CVD (ICD I00-I99) and COPD (ICD J41-J44). Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated by year, sex, age group, race/ethnicity, geographic region, and urbanization status.<h4>Results</h4>Between 1999 and 2020, there were 3,590,124 reported deaths due to coexisting CVD and COPD, with overall AAMR slightly changing from 82.2 to 81.2 per 100,000 population, and a notable rise from 2018 to 2020 (APC: 5.28; 95% CI: 1.83 to 7.22) coinciding with the onset of COVID-19 pandemic. A similar surge in mortality was observed across multiple demographic subgroups, particularly among older adults. Disparities across age groups, sex, race, and geographic location were also observed in the mortality rates due to CVD and COPD. When analyzed by age group, older adults exhibited the highest AAMR at 824.1. Men had higher AAMRs than women (96.5 vs. 60.7). Ethnoracial analysis showed that non-Hispanic (NH) White individuals had the highest AAMRs (82.0), followed by NH American Indian or Alaska Native (74.5), NH Black (63.6), Hispanic (38.1), and NH Asian or Pacific Islander (25.1) individuals. Additionally, non-metropolitan areas had higher AAMRs compared to metropolitan areas (96.2 vs. 70.9).<h4>Conclusions</h4>The findings suggest that mortality rates for CVD and COPD have increased in recent years, coinciding with the onset of the COVID-19 pandemic, which may have exacerbated outcomes in vulnerable populations. The study highlights the need for targeted interventions to address the overlapping impacts of CVD and COPD, especially in high-risk groups. |
| format | Article |
| id | doaj-art-73d1c60cec904bbfbbeacc6e2d162a27 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-73d1c60cec904bbfbbeacc6e2d162a272025-02-09T05:30:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031759210.1371/journal.pone.0317592Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020.Aman GoyalHumza SaeedWania SultanAjeet SinghAbdullahMuhammad Khubaib ArshadZubair AminMah I Kan ChangezGauranga MahalwarRozi KhanWael AlJaroudi<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) greatly influence morbidity and mortality, with COPD patients frequently suffering from cardiovascular comorbidities like coronary heart disease and stroke. This study analyzes mortality trends and disparities among individuals in the United States (US) affected by both CVD and COPD.<h4>Methods</h4>This study analyzed death certificates from the CDC WONDER database for individuals aged 25 and older who died between 1999 and 2020 with both CVD (ICD I00-I99) and COPD (ICD J41-J44). Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated by year, sex, age group, race/ethnicity, geographic region, and urbanization status.<h4>Results</h4>Between 1999 and 2020, there were 3,590,124 reported deaths due to coexisting CVD and COPD, with overall AAMR slightly changing from 82.2 to 81.2 per 100,000 population, and a notable rise from 2018 to 2020 (APC: 5.28; 95% CI: 1.83 to 7.22) coinciding with the onset of COVID-19 pandemic. A similar surge in mortality was observed across multiple demographic subgroups, particularly among older adults. Disparities across age groups, sex, race, and geographic location were also observed in the mortality rates due to CVD and COPD. When analyzed by age group, older adults exhibited the highest AAMR at 824.1. Men had higher AAMRs than women (96.5 vs. 60.7). Ethnoracial analysis showed that non-Hispanic (NH) White individuals had the highest AAMRs (82.0), followed by NH American Indian or Alaska Native (74.5), NH Black (63.6), Hispanic (38.1), and NH Asian or Pacific Islander (25.1) individuals. Additionally, non-metropolitan areas had higher AAMRs compared to metropolitan areas (96.2 vs. 70.9).<h4>Conclusions</h4>The findings suggest that mortality rates for CVD and COPD have increased in recent years, coinciding with the onset of the COVID-19 pandemic, which may have exacerbated outcomes in vulnerable populations. The study highlights the need for targeted interventions to address the overlapping impacts of CVD and COPD, especially in high-risk groups.https://doi.org/10.1371/journal.pone.0317592 |
| spellingShingle | Aman Goyal Humza Saeed Wania Sultan Ajeet Singh Abdullah Muhammad Khubaib Arshad Zubair Amin Mah I Kan Changez Gauranga Mahalwar Rozi Khan Wael AlJaroudi Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. PLoS ONE |
| title | Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. |
| title_full | Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. |
| title_fullStr | Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. |
| title_full_unstemmed | Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. |
| title_short | Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020. |
| title_sort | mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease a retrospective analysis of deaths in the united states from 1999 2020 |
| url | https://doi.org/10.1371/journal.pone.0317592 |
| work_keys_str_mv | AT amangoyal mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT humzasaeed mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT waniasultan mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT ajeetsingh mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT abdullah mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT muhammadkhubaibarshad mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT zubairamin mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT mahikanchangez mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT gaurangamahalwar mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT rozikhan mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 AT waelaljaroudi mortalitytrendsanddisparitiesforcoexistingchronicobstructivepulmonarydiseaseandcardiovasculardiseasearetrospectiveanalysisofdeathsintheunitedstatesfrom19992020 |