The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It
<i>Acinetobacter baumannii</i> is considered one of the prioritized ESKAPE microorganisms for the research and development of novel treatments by the World Health Organization, especially because of its remarkable persistence and drug resistance. In this review, we describe how this can...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/14/1/85 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589334598909952 |
|---|---|
| author | Viola Camilla Scoffone Gabriele Trespidi Giulia Barbieri Arooba Arshad Aygun Israyilova Silvia Buroni |
| author_facet | Viola Camilla Scoffone Gabriele Trespidi Giulia Barbieri Arooba Arshad Aygun Israyilova Silvia Buroni |
| author_sort | Viola Camilla Scoffone |
| collection | DOAJ |
| description | <i>Acinetobacter baumannii</i> is considered one of the prioritized ESKAPE microorganisms for the research and development of novel treatments by the World Health Organization, especially because of its remarkable persistence and drug resistance. In this review, we describe how this can be acquired by the enzymatic degradation of antibiotics, target site modification, altered membrane permeability, multidrug efflux pumps, and their ability to form biofilms. Also, the evolution of drug resistance in <i>A. baumannii</i>, which is mainly driven by mobile genetic elements, is reported, with particular reference to plasmid-associated resistance, resistance islands, and insertion sequences. Finally, an overview of existing, new, and alternative therapies is provided. |
| format | Article |
| id | doaj-art-73cf3fdcafda479c9d4d38129f9ef43b |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-73cf3fdcafda479c9d4d38129f9ef43b2025-01-24T13:18:55ZengMDPI AGAntibiotics2079-63822025-01-011418510.3390/antibiotics14010085The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight ItViola Camilla Scoffone0Gabriele Trespidi1Giulia Barbieri2Arooba Arshad3Aygun Israyilova4Silvia Buroni5Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, ItalyLaboratory of Microbiology, Center of Excellence, Baku State University, AZ1148 Baku, AzerbaijanDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy<i>Acinetobacter baumannii</i> is considered one of the prioritized ESKAPE microorganisms for the research and development of novel treatments by the World Health Organization, especially because of its remarkable persistence and drug resistance. In this review, we describe how this can be acquired by the enzymatic degradation of antibiotics, target site modification, altered membrane permeability, multidrug efflux pumps, and their ability to form biofilms. Also, the evolution of drug resistance in <i>A. baumannii</i>, which is mainly driven by mobile genetic elements, is reported, with particular reference to plasmid-associated resistance, resistance islands, and insertion sequences. Finally, an overview of existing, new, and alternative therapies is provided.https://www.mdpi.com/2079-6382/14/1/85<i>Acinetobacter baumannii</i>drug resistancenew therapy |
| spellingShingle | Viola Camilla Scoffone Gabriele Trespidi Giulia Barbieri Arooba Arshad Aygun Israyilova Silvia Buroni The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It Antibiotics <i>Acinetobacter baumannii</i> drug resistance new therapy |
| title | The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It |
| title_full | The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It |
| title_fullStr | The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It |
| title_full_unstemmed | The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It |
| title_short | The Evolution of Antimicrobial Resistance in <i>Acinetobacter baumannii</i> and New Strategies to Fight It |
| title_sort | evolution of antimicrobial resistance in i acinetobacter baumannii i and new strategies to fight it |
| topic | <i>Acinetobacter baumannii</i> drug resistance new therapy |
| url | https://www.mdpi.com/2079-6382/14/1/85 |
| work_keys_str_mv | AT violacamillascoffone theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT gabrieletrespidi theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT giuliabarbieri theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT aroobaarshad theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT aygunisrayilova theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT silviaburoni theevolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT violacamillascoffone evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT gabrieletrespidi evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT giuliabarbieri evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT aroobaarshad evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT aygunisrayilova evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit AT silviaburoni evolutionofantimicrobialresistanceiniacinetobacterbaumanniiiandnewstrategiestofightit |