Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study
Background Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. Methods and Results The associations between systemic arterial me...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-12-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850082566383599616 |
|---|---|
| author | Nadine Al‐Naamani Julio A. Chirinos Payman Zamani Robin Ruthazer Jessica K. Paulus Kari E. Roberts R. Graham Barr Joao A. Lima David A. Bluemke Richard Kronmal Steven M. Kawut |
| author_facet | Nadine Al‐Naamani Julio A. Chirinos Payman Zamani Robin Ruthazer Jessica K. Paulus Kari E. Roberts R. Graham Barr Joao A. Lima David A. Bluemke Richard Kronmal Steven M. Kawut |
| author_sort | Nadine Al‐Naamani |
| collection | DOAJ |
| description | Background Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. Methods and Results The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end‐systolic [RVESV] and end‐diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi‐Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non‐Hispanic white, 25% Chinese‐American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1‐mL/mm Hg decrease in TAC was associated with 3.9‐mL smaller RVESV, 7.6‐mL smaller RVEDV, and 2.4‐g lower RV mass. A 5‐Wood‐unit increase in SVR was associated with 0.6‐mL decrease in RVESV, 1.7‐mL decrease in RVEDV, and 0.4‐g decrease in RV mass. A 1% increase in AI was associated with 0.2‐mL decrease in RVEDV. We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in RV volumes and mass. Conclusions Markers of increased systemic arterial load were associated with smaller RV volumes and lower RV mass in a population of adults without clinical cardiovascular disease. |
| format | Article |
| id | doaj-art-73cc0d51d2a1497a97bbab987eb1713d |
| institution | DOAJ |
| issn | 2047-9980 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-73cc0d51d2a1497a97bbab987eb1713d2025-08-20T02:44:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-12-0151210.1161/JAHA.116.004162Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle StudyNadine Al‐Naamani0Julio A. Chirinos1Payman Zamani2Robin Ruthazer3Jessica K. Paulus4Kari E. Roberts5R. Graham Barr6Joao A. Lima7David A. Bluemke8Richard Kronmal9Steven M. Kawut10Department of Medicine Tufts Medical Center Boston MADepartment of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PADepartment of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PAClinical and Translational Science Institute Tufts Medical Center Boston MAClinical and Translational Science Institute Tufts Medical Center Boston MADepartment of Medicine Tufts Medical Center Boston MADepartment of Medicine College of Physicians and Surgeons Columbia University New York NYDepartment of Medicine Johns Hopkins University Baltimore MDRadiology and Imaging Sciences National Institutes of Health/Clinical Center Bethesda MDDepartment of Biostatistics University of Washington Seattle WADepartment of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PABackground Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. Methods and Results The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end‐systolic [RVESV] and end‐diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi‐Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non‐Hispanic white, 25% Chinese‐American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1‐mL/mm Hg decrease in TAC was associated with 3.9‐mL smaller RVESV, 7.6‐mL smaller RVEDV, and 2.4‐g lower RV mass. A 5‐Wood‐unit increase in SVR was associated with 0.6‐mL decrease in RVESV, 1.7‐mL decrease in RVEDV, and 0.4‐g decrease in RV mass. A 1% increase in AI was associated with 0.2‐mL decrease in RVEDV. We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in RV volumes and mass. Conclusions Markers of increased systemic arterial load were associated with smaller RV volumes and lower RV mass in a population of adults without clinical cardiovascular disease.https://www.ahajournals.org/doi/10.1161/JAHA.116.004162arterial stiffnessarterymagnetic resonance imagingright ventricleventricle |
| spellingShingle | Nadine Al‐Naamani Julio A. Chirinos Payman Zamani Robin Ruthazer Jessica K. Paulus Kari E. Roberts R. Graham Barr Joao A. Lima David A. Bluemke Richard Kronmal Steven M. Kawut Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease arterial stiffness artery magnetic resonance imaging right ventricle ventricle |
| title | Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study |
| title_full | Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study |
| title_fullStr | Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study |
| title_full_unstemmed | Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study |
| title_short | Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study |
| title_sort | association of systemic arterial properties with right ventricular morphology the multi ethnic study of atherosclerosis mesa right ventricle study |
| topic | arterial stiffness artery magnetic resonance imaging right ventricle ventricle |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.004162 |
| work_keys_str_mv | AT nadinealnaamani associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT julioachirinos associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT paymanzamani associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT robinruthazer associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT jessicakpaulus associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT karieroberts associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT rgrahambarr associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT joaoalima associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT davidabluemke associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT richardkronmal associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy AT stevenmkawut associationofsystemicarterialpropertieswithrightventricularmorphologythemultiethnicstudyofatherosclerosismesarightventriclestudy |