Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation
Background. Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world. Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/719202 |
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| _version_ | 1832558937952485376 |
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| author | Zhongxia Wang Junhua Wu Guang Zhang Yin Cao Chunping Jiang Yitao Ding |
| author_facet | Zhongxia Wang Junhua Wu Guang Zhang Yin Cao Chunping Jiang Yitao Ding |
| author_sort | Zhongxia Wang |
| collection | DOAJ |
| description | Background. Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world. Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34b/c T>C rs4938723 with the risk of HCC. However the results are inconsistent and inconclusive. In this present study, we conducted a meta-analysis to comprehensively evaluate potential associations between the two SNPs and HCC susceptibility. Methods. Through a systematic literature search, 8-case-control studies involving 5464 subjects were identified and included in this meta-analysis. The association between the two common SNPs and HCC risk was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Our results showed no significant association between rs3746444 and susceptibility to HCC, whereas variant genotypes of rs4938723 were associated with increased HCC risk in allele frequency model and heterozygous model (C versus T, OR=1.11, 95% CI: 1.01–1.23, P=0.04; TC versus TT, OR=1.19, 95% CI: 1.03–1.37, P=0.02). Conclusions. The current evidence did not support association between rs3746444 and HCC risk. SNP rs4938723 may be associated with susceptibility to HCC. Further well-designed studies are required to clarify the relationships between the two SNPs and HCC risk. |
| format | Article |
| id | doaj-art-73c9aed4258c496a897306b555687144 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-73c9aed4258c496a897306b5556871442025-02-03T01:31:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/719202719202Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based EvaluationZhongxia Wang0Junhua Wu1Guang Zhang2Yin Cao3Chunping Jiang4Yitao Ding5Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaSchool of Medicine, Nanjing University, Nanjing, Jiangsu 210093, ChinaJiangsu Province's Key Medical Center for Liver Surgery, Nanjing, Jiangsu 210008, ChinaDepartment of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaBackground. Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world. Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34b/c T>C rs4938723 with the risk of HCC. However the results are inconsistent and inconclusive. In this present study, we conducted a meta-analysis to comprehensively evaluate potential associations between the two SNPs and HCC susceptibility. Methods. Through a systematic literature search, 8-case-control studies involving 5464 subjects were identified and included in this meta-analysis. The association between the two common SNPs and HCC risk was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Our results showed no significant association between rs3746444 and susceptibility to HCC, whereas variant genotypes of rs4938723 were associated with increased HCC risk in allele frequency model and heterozygous model (C versus T, OR=1.11, 95% CI: 1.01–1.23, P=0.04; TC versus TT, OR=1.19, 95% CI: 1.03–1.37, P=0.02). Conclusions. The current evidence did not support association between rs3746444 and HCC risk. SNP rs4938723 may be associated with susceptibility to HCC. Further well-designed studies are required to clarify the relationships between the two SNPs and HCC risk.http://dx.doi.org/10.1155/2013/719202 |
| spellingShingle | Zhongxia Wang Junhua Wu Guang Zhang Yin Cao Chunping Jiang Yitao Ding Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation Gastroenterology Research and Practice |
| title | Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation |
| title_full | Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation |
| title_fullStr | Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation |
| title_full_unstemmed | Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation |
| title_short | Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation |
| title_sort | associations of mir 499 and mir 34b c polymorphisms with susceptibility to hepatocellular carcinoma an evidence based evaluation |
| url | http://dx.doi.org/10.1155/2013/719202 |
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