Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive
Objective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to...
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Thieme Revinter Publicações
2013-10-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001100780&lng=en&tlng=en |
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| author | Yara Dadalti Fragoso Maria Fernanda Mendes Walter Oleschko Arruda Jefferson Becker Joseph Bruno Bidin Brooks Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Renan Barros Domingues Maria Lucia Brito Ferreira Alessandro Finkelsztejn Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Goncalves Damacio Ramon Kaimen-Maciel Rogerio de Rizo Morales Andre Muniz Heloisa Helena Ruocco Pedro Rippel Salgado Livia Brito Bezerra de Albuquerque Rodrigo Assad Diniz da Gama Sergio Georgeto Josiane Lopes Celso Luis Silva Oliveira Francisco Tomaz Meneses Oliveira Juliana Safanelli Patricia Correia de Oliveira Saldanha Massaco Satomi |
| author_facet | Yara Dadalti Fragoso Maria Fernanda Mendes Walter Oleschko Arruda Jefferson Becker Joseph Bruno Bidin Brooks Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Renan Barros Domingues Maria Lucia Brito Ferreira Alessandro Finkelsztejn Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Goncalves Damacio Ramon Kaimen-Maciel Rogerio de Rizo Morales Andre Muniz Heloisa Helena Ruocco Pedro Rippel Salgado Livia Brito Bezerra de Albuquerque Rodrigo Assad Diniz da Gama Sergio Georgeto Josiane Lopes Celso Luis Silva Oliveira Francisco Tomaz Meneses Oliveira Juliana Safanelli Patricia Correia de Oliveira Saldanha Massaco Satomi |
| author_sort | Yara Dadalti Fragoso |
| collection | DOAJ |
| description | Objective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab. Method Qualitative detection of the JCV in the serum was performed with real-time polymerase chain reaction (PCR). Results In a group of 168 patients with MS who were undergoing treatment with natalizumab, JCV-DNA was detectable in 86 (51.2%) patients. Discussion Data on JCV-DNA in Brazil add to the worldwide assessment of the prevalence of the JCV in MS patients requiring treatment with natalizumab. |
| format | Article |
| id | doaj-art-73c6cb87d7fb4cada41a3d8bb0d36c6a |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2013-10-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-73c6cb87d7fb4cada41a3d8bb0d36c6a2025-08-20T03:19:10ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272013-10-01711078078210.1590/0004-282X20130121S0004-282X2013001100780Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positiveYara Dadalti FragosoMaria Fernanda MendesWalter Oleschko ArrudaJefferson BeckerJoseph Bruno Bidin BrooksMargarete de Jesus CarvalhoElizabeth Regina Comini-FrotaRenan Barros DominguesMaria Lucia Brito FerreiraAlessandro FinkelsztejnPaulo Diniz da GamaSidney GomesMarcus Vinicius Magno GoncalvesDamacio Ramon Kaimen-MacielRogerio de Rizo MoralesAndre MunizHeloisa Helena RuoccoPedro Rippel SalgadoLivia Brito Bezerra de AlbuquerqueRodrigo Assad Diniz da GamaSergio GeorgetoJosiane LopesCelso Luis Silva OliveiraFrancisco Tomaz Meneses OliveiraJuliana SafanelliPatricia Correia de Oliveira SaldanhaMassaco SatomiObjective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab. Method Qualitative detection of the JCV in the serum was performed with real-time polymerase chain reaction (PCR). Results In a group of 168 patients with MS who were undergoing treatment with natalizumab, JCV-DNA was detectable in 86 (51.2%) patients. Discussion Data on JCV-DNA in Brazil add to the worldwide assessment of the prevalence of the JCV in MS patients requiring treatment with natalizumab.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001100780&lng=en&tlng=enesclerose multiplanatalizumabeJC virusleucoencefalopatia multifocal progressiva |
| spellingShingle | Yara Dadalti Fragoso Maria Fernanda Mendes Walter Oleschko Arruda Jefferson Becker Joseph Bruno Bidin Brooks Margarete de Jesus Carvalho Elizabeth Regina Comini-Frota Renan Barros Domingues Maria Lucia Brito Ferreira Alessandro Finkelsztejn Paulo Diniz da Gama Sidney Gomes Marcus Vinicius Magno Goncalves Damacio Ramon Kaimen-Maciel Rogerio de Rizo Morales Andre Muniz Heloisa Helena Ruocco Pedro Rippel Salgado Livia Brito Bezerra de Albuquerque Rodrigo Assad Diniz da Gama Sergio Georgeto Josiane Lopes Celso Luis Silva Oliveira Francisco Tomaz Meneses Oliveira Juliana Safanelli Patricia Correia de Oliveira Saldanha Massaco Satomi Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive Arquivos de Neuro-Psiquiatria esclerose multipla natalizumabe JC virus leucoencefalopatia multifocal progressiva |
| title | Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive |
| title_full | Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive |
| title_fullStr | Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive |
| title_full_unstemmed | Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive |
| title_short | Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive |
| title_sort | nearly one half of brazilian patients with multiple sclerosis using natalizumab are dna jc virus positive |
| topic | esclerose multipla natalizumabe JC virus leucoencefalopatia multifocal progressiva |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001100780&lng=en&tlng=en |
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