Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment, methylation profiles vary by tissue due to variance in cel...
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Taylor & Francis Group
2025-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2025.2508067 |
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| author | Jagadeesh Puvvula Joseph M. Braun Emily A. DeFranco Shuk-Mei Ho Yuet-Kin Leung Shouxiong Huang Xiang Zhang Ann M. Vuong Stephani S. Kim Zana Percy Aimin Chen |
| author_facet | Jagadeesh Puvvula Joseph M. Braun Emily A. DeFranco Shuk-Mei Ho Yuet-Kin Leung Shouxiong Huang Xiang Zhang Ann M. Vuong Stephani S. Kim Zana Percy Aimin Chen |
| author_sort | Jagadeesh Puvvula |
| collection | DOAJ |
| description | The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment, methylation profiles vary by tissue due to variance in cell populations, function, and life stage. As tissue differences extensively contribute to the DNA methylation patterns, using surrogate samples such as cord blood may result in inconsistent findings. In this study, we aim to quantify the correlation of cytosine-phosphate-guanine dinucleotides (CpGs) between paired cord blood and placenta samples. Using the Infinium Human Methylation 450 K BeadChip, we compared methylation patterns in cord blood mononuclear cells (CBMC; n = 54), the maternally-facing side of placental tissue (MP; n = 68), and the fetal-facing side of placental tissue (FP; n = 67). Methylation patterns from the FP (6,021 CpGs) were significantly correlated with CBMC compared to the MP (2,862 CpGs). These CpGs were related to the biological (mitotic cell) process and molecular function (ribonucleoprotein complex binding). Our findings quantified CpG site correlation between cord blood and placenta, providing a valuable reference for future studies on placental health that rely on cord blood methylation in the absence of placental biospecimens. |
| format | Article |
| id | doaj-art-73bd84b14d7e4e37b53fede4178870d7 |
| institution | OA Journals |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-73bd84b14d7e4e37b53fede4178870d72025-08-20T02:25:59ZengTaylor & Francis GroupEpigenetics1559-22941559-23082025-12-0120110.1080/15592294.2025.2508067Epigenetic signatures of maternal-fetal health: insights from cord blood and placentaJagadeesh Puvvula0Joseph M. Braun1Emily A. DeFranco2Shuk-Mei Ho3Yuet-Kin Leung4Shouxiong Huang5Xiang Zhang6Ann M. Vuong7Stephani S. Kim8Zana Percy9Aimin Chen10Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USADepartment of Epidemiology, Brown University, Providence, RI, USADepartment of Obstetrics and Gynecology, College of Medicine, University of Kentucky, Lexington, KY, USADepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USAPathogen-Host Interaction Program, Texas Biomedical Research Institute, San Antonio, TX, USADepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USADepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, Las Vegas, NV, USAHealth Research, Battelle Memorial Institute, Columbus, OH, USADepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USADepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USAThe placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment, methylation profiles vary by tissue due to variance in cell populations, function, and life stage. As tissue differences extensively contribute to the DNA methylation patterns, using surrogate samples such as cord blood may result in inconsistent findings. In this study, we aim to quantify the correlation of cytosine-phosphate-guanine dinucleotides (CpGs) between paired cord blood and placenta samples. Using the Infinium Human Methylation 450 K BeadChip, we compared methylation patterns in cord blood mononuclear cells (CBMC; n = 54), the maternally-facing side of placental tissue (MP; n = 68), and the fetal-facing side of placental tissue (FP; n = 67). Methylation patterns from the FP (6,021 CpGs) were significantly correlated with CBMC compared to the MP (2,862 CpGs). These CpGs were related to the biological (mitotic cell) process and molecular function (ribonucleoprotein complex binding). Our findings quantified CpG site correlation between cord blood and placenta, providing a valuable reference for future studies on placental health that rely on cord blood methylation in the absence of placental biospecimens.https://www.tandfonline.com/doi/10.1080/15592294.2025.2508067DNA methylationplacentacord blood mononuclear cells |
| spellingShingle | Jagadeesh Puvvula Joseph M. Braun Emily A. DeFranco Shuk-Mei Ho Yuet-Kin Leung Shouxiong Huang Xiang Zhang Ann M. Vuong Stephani S. Kim Zana Percy Aimin Chen Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta Epigenetics DNA methylation placenta cord blood mononuclear cells |
| title | Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta |
| title_full | Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta |
| title_fullStr | Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta |
| title_full_unstemmed | Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta |
| title_short | Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta |
| title_sort | epigenetic signatures of maternal fetal health insights from cord blood and placenta |
| topic | DNA methylation placenta cord blood mononuclear cells |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2025.2508067 |
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