Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children
This report describes a rare case of a pediatric tenosynovial giant cell tumor (TSGCT) with a delayed diagnosis. A 9-year-old boy presented with a 3-month history of knee pain and swelling, initially attributed to a femoral non-ossifying fibroma and arthritis based on computed tomography findings an...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/3/281 |
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| author | Jiro Ichikawa Satoshi Ochiai Tomonori Kawasaki Kojiro Onohara Masanori Wako Hirotaka Haro Tetsuo Hagino |
| author_facet | Jiro Ichikawa Satoshi Ochiai Tomonori Kawasaki Kojiro Onohara Masanori Wako Hirotaka Haro Tetsuo Hagino |
| author_sort | Jiro Ichikawa |
| collection | DOAJ |
| description | This report describes a rare case of a pediatric tenosynovial giant cell tumor (TSGCT) with a delayed diagnosis. A 9-year-old boy presented with a 3-month history of knee pain and swelling, initially attributed to a femoral non-ossifying fibroma and arthritis based on computed tomography findings and slightly elevated C-reactive protein levels. The symptoms persisted despite medical treatment. Magnetic resonance imaging (MRI) revealed a tumor in the posterior compartment. He underwent surgery, and the pathology confirmed the diagnosis of localized TSGCT. Six months postoperatively, the patient remained asymptomatic. Pediatric knee pain is a complex symptom associated with inflammatory conditions and benign and malignant tumors. Benign tumors, as in this case, can be misdiagnosed as arthritis, delaying diagnosis and treatment. MRI is recommended in cases involving symptom persistence. However, histopathological, immunohistochemical, and morphological examinations are crucial for definitive diagnosis, particularly when the imaging findings are inconclusive. |
| format | Article |
| id | doaj-art-73bc7ddb441944038ed6746da24a43fe |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-73bc7ddb441944038ed6746da24a43fe2025-08-20T02:12:25ZengMDPI AGDiagnostics2075-44182025-01-0115328110.3390/diagnostics15030281Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in ChildrenJiro Ichikawa0Satoshi Ochiai1Tomonori Kawasaki2Kojiro Onohara3Masanori Wako4Hirotaka Haro5Tetsuo Hagino6Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Yamanashi, JapanDepartment of Orthopaedic Surgery, National Hospital Organization (NHO), Kofu National Hospital, Kofu 400-8533, Yamanashi, JapanDepartment of Pathology, Saitama Medical University International Medical Center, Hidaka 350-1298, Saitama, JapanDepartment of Radiology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Yamanashi, JapanDepartment of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Yamanashi, JapanDepartment of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Yamanashi, JapanDepartment of Orthopaedic Surgery, National Hospital Organization (NHO), Kofu National Hospital, Kofu 400-8533, Yamanashi, JapanThis report describes a rare case of a pediatric tenosynovial giant cell tumor (TSGCT) with a delayed diagnosis. A 9-year-old boy presented with a 3-month history of knee pain and swelling, initially attributed to a femoral non-ossifying fibroma and arthritis based on computed tomography findings and slightly elevated C-reactive protein levels. The symptoms persisted despite medical treatment. Magnetic resonance imaging (MRI) revealed a tumor in the posterior compartment. He underwent surgery, and the pathology confirmed the diagnosis of localized TSGCT. Six months postoperatively, the patient remained asymptomatic. Pediatric knee pain is a complex symptom associated with inflammatory conditions and benign and malignant tumors. Benign tumors, as in this case, can be misdiagnosed as arthritis, delaying diagnosis and treatment. MRI is recommended in cases involving symptom persistence. However, histopathological, immunohistochemical, and morphological examinations are crucial for definitive diagnosis, particularly when the imaging findings are inconclusive.https://www.mdpi.com/2075-4418/15/3/281tenosynovial giant cell tumorlocalizeddifferential diagnosisknee pain in childrenmagnetic resonance imaginghistopathology |
| spellingShingle | Jiro Ichikawa Satoshi Ochiai Tomonori Kawasaki Kojiro Onohara Masanori Wako Hirotaka Haro Tetsuo Hagino Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children Diagnostics tenosynovial giant cell tumor localized differential diagnosis knee pain in children magnetic resonance imaging histopathology |
| title | Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children |
| title_full | Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children |
| title_fullStr | Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children |
| title_full_unstemmed | Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children |
| title_short | Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children |
| title_sort | diagnostic challenge of localized tenosynovial giant cell tumor in children |
| topic | tenosynovial giant cell tumor localized differential diagnosis knee pain in children magnetic resonance imaging histopathology |
| url | https://www.mdpi.com/2075-4418/15/3/281 |
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