Colonic strictures in Crohn’s disease: a non-surgical survival
Background Colonic stenosis in Crohn’s disease (CD) is uncommon, and data on surgery-free survival are limited. This study aimed to determine surgery-free survival rates and identify associated factors.Patients and methods A retrospective study was conducted from 2003 to 2022, including patients wit...
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Taylor & Francis Group
2025-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2025.2455911 |
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| author | Sarra Laabidi Hamed Aboubecrine Salma Souissi Donia Gouiaa Asma Labidi Nadia Ben Mustapha Anis Haddad Amine Sebai Meriem Serghini Monia Fekih Hanene Jaziri Jalel Boubaker |
| author_facet | Sarra Laabidi Hamed Aboubecrine Salma Souissi Donia Gouiaa Asma Labidi Nadia Ben Mustapha Anis Haddad Amine Sebai Meriem Serghini Monia Fekih Hanene Jaziri Jalel Boubaker |
| author_sort | Sarra Laabidi |
| collection | DOAJ |
| description | Background Colonic stenosis in Crohn’s disease (CD) is uncommon, and data on surgery-free survival are limited. This study aimed to determine surgery-free survival rates and identify associated factors.Patients and methods A retrospective study was conducted from 2003 to 2022, including patients with CD complicated by colonic stenosis. Patients with uncertain diagnoses or follow-up periods of less than six months were excluded.Results Fifty-six patients were included (median age 44 years [range 14-65], male-to-female ratio = 0.93). Surgery-free survival rates were 58.9% at 6 months, 43.7% at 2 years, and 31.7% at 5 years, with an average surgery-free survival of 46.7 months. Univariate analysis showed that joint manifestations (p = 0.01), corticosteroids (p = 0.02), anti-TNF alpha (p = 0.02), salicylates (p = 0.02), and azathioprine (p = 0.01) increased surgery-free survival. Complications such as collections or internal fistulas (p = 0.03), parietal ulceration on imaging (p = 0.01), and acute intestinal obstruction (p = 0.01) were associated with reduced surgery-free survival. In multivariate analysis, biologic therapy was the only independent protective factor against surgery (p = 0.001, OR = 0.19).Conclusion The early introduction of biologic therapy is crucial for increasing surgery-free survival in patients with colonic stenosis in CD, given the limited effectiveness of conventional treatments. |
| format | Article |
| id | doaj-art-73b9c1eac74842ed80cdf05d99164524 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-73b9c1eac74842ed80cdf05d991645242025-01-25T12:36:52ZengTaylor & Francis GroupFuture Science OA2056-56232025-12-0111110.1080/20565623.2025.2455911Colonic strictures in Crohn’s disease: a non-surgical survivalSarra Laabidi0Hamed Aboubecrine1Salma Souissi2Donia Gouiaa3Asma Labidi4Nadia Ben Mustapha5Anis Haddad6Amine Sebai7Meriem Serghini8Monia Fekih9Hanene Jaziri10Jalel Boubaker11Gastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaSurgery Department “A”, La Rabta Hospital, Tunis, TunisiaSurgery Department “A”, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaGastroenterology Department, Sahloul Hospital, Sousse, TunisiaGastroenterology Department, Sahloul Hospital, Sousse, TunisiaGastroenterology Department, La Rabta Hospital, Tunis, TunisiaBackground Colonic stenosis in Crohn’s disease (CD) is uncommon, and data on surgery-free survival are limited. This study aimed to determine surgery-free survival rates and identify associated factors.Patients and methods A retrospective study was conducted from 2003 to 2022, including patients with CD complicated by colonic stenosis. Patients with uncertain diagnoses or follow-up periods of less than six months were excluded.Results Fifty-six patients were included (median age 44 years [range 14-65], male-to-female ratio = 0.93). Surgery-free survival rates were 58.9% at 6 months, 43.7% at 2 years, and 31.7% at 5 years, with an average surgery-free survival of 46.7 months. Univariate analysis showed that joint manifestations (p = 0.01), corticosteroids (p = 0.02), anti-TNF alpha (p = 0.02), salicylates (p = 0.02), and azathioprine (p = 0.01) increased surgery-free survival. Complications such as collections or internal fistulas (p = 0.03), parietal ulceration on imaging (p = 0.01), and acute intestinal obstruction (p = 0.01) were associated with reduced surgery-free survival. In multivariate analysis, biologic therapy was the only independent protective factor against surgery (p = 0.001, OR = 0.19).Conclusion The early introduction of biologic therapy is crucial for increasing surgery-free survival in patients with colonic stenosis in CD, given the limited effectiveness of conventional treatments.https://www.tandfonline.com/doi/10.1080/20565623.2025.2455911Inflammatory bowel diseaseCrohn’s diseasecolonic stricturesurgerysurvivalanti TNF alpha therapy |
| spellingShingle | Sarra Laabidi Hamed Aboubecrine Salma Souissi Donia Gouiaa Asma Labidi Nadia Ben Mustapha Anis Haddad Amine Sebai Meriem Serghini Monia Fekih Hanene Jaziri Jalel Boubaker Colonic strictures in Crohn’s disease: a non-surgical survival Future Science OA Inflammatory bowel disease Crohn’s disease colonic stricture surgery survival anti TNF alpha therapy |
| title | Colonic strictures in Crohn’s disease: a non-surgical survival |
| title_full | Colonic strictures in Crohn’s disease: a non-surgical survival |
| title_fullStr | Colonic strictures in Crohn’s disease: a non-surgical survival |
| title_full_unstemmed | Colonic strictures in Crohn’s disease: a non-surgical survival |
| title_short | Colonic strictures in Crohn’s disease: a non-surgical survival |
| title_sort | colonic strictures in crohn s disease a non surgical survival |
| topic | Inflammatory bowel disease Crohn’s disease colonic stricture surgery survival anti TNF alpha therapy |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2025.2455911 |
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