Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterised by a short survival period, high malignancy, strong invasiveness, and high rates of recurrence and metastasis. Due to its unique molecular phenotype, TNBC is insensitive to endocrine therapy or molecu...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-02-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004663 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850110583138942976 |
|---|---|
| author | Tingyu Yang Liqun Dai Jie Liu Yi Lu Meng Pan Lili Pan Lin Ye Liping Yuan Xicheng Li Zhongwu Bei Zhiyong Qian |
| author_facet | Tingyu Yang Liqun Dai Jie Liu Yi Lu Meng Pan Lili Pan Lin Ye Liping Yuan Xicheng Li Zhongwu Bei Zhiyong Qian |
| author_sort | Tingyu Yang |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterised by a short survival period, high malignancy, strong invasiveness, and high rates of recurrence and metastasis. Due to its unique molecular phenotype, TNBC is insensitive to endocrine therapy or molecular targeted therapy. The conventional treatment approach involves systemic chemotherapy for overall management; however, adjuvant chemotherapy after surgery has shown poor efficacy as residual lesions can easily lead to tumour recurrence. Therefore, there is an urgent need to find more effective treatment strategies. Herein, we designed a gold nanocluster coated with a metal-phenol formaldehyde network structure (AuNCs@PDA-Mn) for tumour Photothermal therapy and chemodynamic therapy (PTT and CDT), which induces systemic immune responses to suppress tumour metastasis. Experimental results show that after continuous irradiation for 10 min under an 808 nm laser (1.0W/cm2), AuNCs@PDA-Mn not only exhibits better tumour inhibition both in vitro and in vivo but also triggers stronger immune effects systemically. Therefore, this combined PTT and CDT treatment approach has great potential and provides a clinically relevant and valuable option for triple-negative breast cancer. |
| format | Article |
| id | doaj-art-73b0b7f8f9d44b40816b0aecf44255e4 |
| institution | OA Journals |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-73b0b7f8f9d44b40816b0aecf44255e42025-08-20T02:37:48ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-02-014444746010.1016/j.bioactmat.2024.10.021Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapyTingyu Yang0Liqun Dai1Jie Liu2Yi Lu3Meng Pan4Lili Pan5Lin Ye6Liping Yuan7Xicheng Li8Zhongwu Bei9Zhiyong Qian10Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Nuclear Medicine and Clinical Nuclear Medicine Research Lab, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Corresponding author.Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterised by a short survival period, high malignancy, strong invasiveness, and high rates of recurrence and metastasis. Due to its unique molecular phenotype, TNBC is insensitive to endocrine therapy or molecular targeted therapy. The conventional treatment approach involves systemic chemotherapy for overall management; however, adjuvant chemotherapy after surgery has shown poor efficacy as residual lesions can easily lead to tumour recurrence. Therefore, there is an urgent need to find more effective treatment strategies. Herein, we designed a gold nanocluster coated with a metal-phenol formaldehyde network structure (AuNCs@PDA-Mn) for tumour Photothermal therapy and chemodynamic therapy (PTT and CDT), which induces systemic immune responses to suppress tumour metastasis. Experimental results show that after continuous irradiation for 10 min under an 808 nm laser (1.0W/cm2), AuNCs@PDA-Mn not only exhibits better tumour inhibition both in vitro and in vivo but also triggers stronger immune effects systemically. Therefore, this combined PTT and CDT treatment approach has great potential and provides a clinically relevant and valuable option for triple-negative breast cancer.http://www.sciencedirect.com/science/article/pii/S2452199X24004663Gold nanoclustersPhotothermal therapyChemodynamic therapyImmunotherapyTriple-negative breast cancer |
| spellingShingle | Tingyu Yang Liqun Dai Jie Liu Yi Lu Meng Pan Lili Pan Lin Ye Liping Yuan Xicheng Li Zhongwu Bei Zhiyong Qian Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy Bioactive Materials Gold nanoclusters Photothermal therapy Chemodynamic therapy Immunotherapy Triple-negative breast cancer |
| title | Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy |
| title_full | Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy |
| title_fullStr | Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy |
| title_full_unstemmed | Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy |
| title_short | Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy |
| title_sort | metal phenolic network coated gold nanoclusters for enhanced photothermal chemodynamic immunogenic cancer therapy |
| topic | Gold nanoclusters Photothermal therapy Chemodynamic therapy Immunotherapy Triple-negative breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004663 |
| work_keys_str_mv | AT tingyuyang metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT liqundai metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT jieliu metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT yilu metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT mengpan metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT lilipan metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT linye metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT lipingyuan metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT xichengli metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT zhongwubei metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy AT zhiyongqian metalphenolicnetworkcoatedgoldnanoclustersforenhancedphotothermalchemodynamicimmunogeniccancertherapy |