Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation
Abstract Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the result...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412158 |
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| author | Lei Ren Yangnan Hu Xiaoqiong Ding Menghui Liao Tian Shen Sixing Cao Hui Zhang Hong Cheng Yanru Qi Pan Feng Xinyi Pang Ling Lu Huan Wang Wenwen Liu Renjie Chai Lin Cheng |
| author_facet | Lei Ren Yangnan Hu Xiaoqiong Ding Menghui Liao Tian Shen Sixing Cao Hui Zhang Hong Cheng Yanru Qi Pan Feng Xinyi Pang Ling Lu Huan Wang Wenwen Liu Renjie Chai Lin Cheng |
| author_sort | Lei Ren |
| collection | DOAJ |
| description | Abstract Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA‐PDMS)‐coated cochlear electrode is presented for CI and hearing protection. The porous MA‐PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti3C2Tx MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug‐loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system. |
| format | Article |
| id | doaj-art-73abfedc2f0641aeae9054e12afa0902 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-73abfedc2f0641aeae9054e12afa09022025-08-20T03:26:10ZengWileyAdvanced Science2198-38442025-06-011221n/an/a10.1002/advs.202412158Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear ImplantationLei Ren0Yangnan Hu1Xiaoqiong Ding2Menghui Liao3Tian Shen4Sixing Cao5Hui Zhang6Hong Cheng7Yanru Qi8Pan Feng9Xinyi Pang10Ling Lu11Huan Wang12Wenwen Liu13Renjie Chai14Lin Cheng15State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaDepartment of Otolaryngology‐Head & Neck Surgery West China Hospital Sichuan University Chengdu 610041 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaCollege of Food Science and Engineering Nanjing University of Finance and Economics Nanjing 210023 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaThe Eighth Affiliated Hospital Sun Yat‐Sen University Shenzhen 518033 ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan 250022 ChinaState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 ChinaDepartment of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu 610000 ChinaAbstract Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA‐PDMS)‐coated cochlear electrode is presented for CI and hearing protection. The porous MA‐PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti3C2Tx MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug‐loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.https://doi.org/10.1002/advs.202412158antifibrosiscochlear electrodehydrogelporous PDMStissue engineering |
| spellingShingle | Lei Ren Yangnan Hu Xiaoqiong Ding Menghui Liao Tian Shen Sixing Cao Hui Zhang Hong Cheng Yanru Qi Pan Feng Xinyi Pang Ling Lu Huan Wang Wenwen Liu Renjie Chai Lin Cheng Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation Advanced Science antifibrosis cochlear electrode hydrogel porous PDMS tissue engineering |
| title | Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation |
| title_full | Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation |
| title_fullStr | Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation |
| title_full_unstemmed | Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation |
| title_short | Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation |
| title_sort | multicargo porous cochlear electrode coating for antifibrosis after cochlear implantation |
| topic | antifibrosis cochlear electrode hydrogel porous PDMS tissue engineering |
| url | https://doi.org/10.1002/advs.202412158 |
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