Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease
Parkinson’s disease (PD) is currently a highly prevalent neurodegenerative disease. Its pathogenesis is complex, and there is no effective method to prevent the disease progression. Traditional Chinese medicine (TCM) has a unique advantage in treating PD through the approach of syndrome differentiat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1566479/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849243054841528320 |
|---|---|
| author | Xiangling Zhou Qi Pan |
| author_facet | Xiangling Zhou Qi Pan |
| author_sort | Xiangling Zhou |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is currently a highly prevalent neurodegenerative disease. Its pathogenesis is complex, and there is no effective method to prevent the disease progression. Traditional Chinese medicine (TCM) has a unique advantage in treating PD through the approach of syndrome differentiation. TCM prescriptions for PD can reduce Unified Parkinson’s Disease Rating Scale (UPDRS) scores, improve non-motor symptoms, and decrease adverse drug reactions. Bioactive polysaccharides extracted from prescribed Chinese herbs exhibit diverse biological activities due to their wide range of botanical sources. This review summarizes the pharmacological mechanisms of polysaccharides derived from TCM in managing PD, including inhibition of apoptosis, activation of autophagy, regulation of inflammation, anti-oxidative stress, improvement of mitochondrial function, and neuroprotective effects, aiming to provide a theoretical basis for future research and treatment. |
| format | Article |
| id | doaj-art-73a0902c9bce41c3ac117e1acd0d2398 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-73a0902c9bce41c3ac117e1acd0d23982025-08-20T03:59:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.15664791566479Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s diseaseXiangling ZhouQi PanParkinson’s disease (PD) is currently a highly prevalent neurodegenerative disease. Its pathogenesis is complex, and there is no effective method to prevent the disease progression. Traditional Chinese medicine (TCM) has a unique advantage in treating PD through the approach of syndrome differentiation. TCM prescriptions for PD can reduce Unified Parkinson’s Disease Rating Scale (UPDRS) scores, improve non-motor symptoms, and decrease adverse drug reactions. Bioactive polysaccharides extracted from prescribed Chinese herbs exhibit diverse biological activities due to their wide range of botanical sources. This review summarizes the pharmacological mechanisms of polysaccharides derived from TCM in managing PD, including inhibition of apoptosis, activation of autophagy, regulation of inflammation, anti-oxidative stress, improvement of mitochondrial function, and neuroprotective effects, aiming to provide a theoretical basis for future research and treatment.https://www.frontiersin.org/articles/10.3389/fphar.2025.1566479/fullpolysaccharidestraditional Chinese medicineParkinson’s diseasemolecular mechanismsneuroprotectionresearch progress |
| spellingShingle | Xiangling Zhou Qi Pan Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease Frontiers in Pharmacology polysaccharides traditional Chinese medicine Parkinson’s disease molecular mechanisms neuroprotection research progress |
| title | Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease |
| title_full | Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease |
| title_fullStr | Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease |
| title_full_unstemmed | Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease |
| title_short | Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson’s disease |
| title_sort | research progress on the mechanisms of polysaccharides derived from traditional chinese medicine in the treatment of parkinson s disease |
| topic | polysaccharides traditional Chinese medicine Parkinson’s disease molecular mechanisms neuroprotection research progress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1566479/full |
| work_keys_str_mv | AT xianglingzhou researchprogressonthemechanismsofpolysaccharidesderivedfromtraditionalchinesemedicineinthetreatmentofparkinsonsdisease AT qipan researchprogressonthemechanismsofpolysaccharidesderivedfromtraditionalchinesemedicineinthetreatmentofparkinsonsdisease |