Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol
Abstract Background Obesity is a multifactorial disease reaching pandemic proportions with increasing healthcare costs, advocating the development of better prevention and treatment strategies. Previous research indicates that the gut microbiome plays an important role in metabolic, hormonal, and ne...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s40795-024-00971-6 |
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| author | Meghedi Vartanian Konrad Jakob Endres Yee Teng Lee Silke Friedrich Marie-Theres Meemken Imke Schamarek Kerstin Rohde-Zimmermann Robin Schürfeld Lina Eisenberg Anja Hilbert Frauke Beyer Michael Stumvoll Julia Sacher Arno Villringer Julia F. Christensen A. Veronica Witte |
| author_facet | Meghedi Vartanian Konrad Jakob Endres Yee Teng Lee Silke Friedrich Marie-Theres Meemken Imke Schamarek Kerstin Rohde-Zimmermann Robin Schürfeld Lina Eisenberg Anja Hilbert Frauke Beyer Michael Stumvoll Julia Sacher Arno Villringer Julia F. Christensen A. Veronica Witte |
| author_sort | Meghedi Vartanian |
| collection | DOAJ |
| description | Abstract Background Obesity is a multifactorial disease reaching pandemic proportions with increasing healthcare costs, advocating the development of better prevention and treatment strategies. Previous research indicates that the gut microbiome plays an important role in metabolic, hormonal, and neuronal cross-talk underlying eating behavior. We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT). Method This study uses a parallel arm RCT design with a 26-week intervention period. We plan to enroll 90 participants (male/diverse/female) living with overweight or obesity, defined as either a Waist-to-Hip Ratio (WHR) ≥ 0.9 (male)/0.85 (diverse, female) or a Body Mass Index (BMI) ≥ 25 kg/m2. Key inclusion criteria are 18–60 years of age and exclusion criteria are type 2 diabetes, psychiatric disease, and Magnetic Resonance Imaging (MRI) contraindications. The interventions comprise either a daily supplementary intake of 30 g soluble fiber (inulin), or weekly neurocognitive behavioral group sessions, compared to placebo (equicaloric maltodextrin). At baseline and follow-up, food decision-making is assessed utilizing task-based MRI. Secondary outcome measures include structural MRI, eating habits, lifestyle factors, personality traits, and mood. Further, we obtain fecal and blood samples to investigate gut microbiome composition and related metabolites. Discussion This study relies on expanding research suggesting that dietary prebiotics could improve gut microbiome composition, leading to beneficial effects on gut-brain signaling and higher-order cognitive functions. In parallel, neurocognitive behavioral interventions have been proposed to improve unhealthy eating habits and metabolic status. However, causal evidence on how these “bottom-up” and “top-down” processes affect food decision-making and neuronal correlates in humans is still scarce. In addition, microbiome, and gut-brain-axis-related mediating mechanisms remain unclear. The present study proposes a comprehensive approach to assess the effects of these gut-brain-related processes influencing food decision-making in overweight and obesity. Trial registration ClinicalTrials.gov NCT05353504. Retrospectively registered on 29 April 2022. |
| format | Article |
| id | doaj-art-739f04f4f237426e967bcb910d4085b3 |
| institution | Kabale University |
| issn | 2055-0928 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Nutrition |
| spelling | doaj-art-739f04f4f237426e967bcb910d4085b32025-01-19T12:13:19ZengBMCBMC Nutrition2055-09282025-01-0111111510.1186/s40795-024-00971-6Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocolMeghedi Vartanian0Konrad Jakob Endres1Yee Teng Lee2Silke Friedrich3Marie-Theres Meemken4Imke Schamarek5Kerstin Rohde-Zimmermann6Robin Schürfeld7Lina Eisenberg8Anja Hilbert9Frauke Beyer10Michael Stumvoll11Julia Sacher12Arno Villringer13Julia F. Christensen14A. Veronica Witte15Clinic for Cognitive Neurology, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterDepartment of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of LeipzigHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University Hospital LeipzigDepartment of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of LeipzigClinic for Cognitive Neurology, University of Leipzig Medical CenterIntegrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterDepartment of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of LeipzigClinic for Cognitive Neurology, University of Leipzig Medical CenterClinic for Cognitive Neurology, University of Leipzig Medical CenterDepartment of Cognitive Neuropsychology, Max Planck Institute for Empirical AestheticsClinic for Cognitive Neurology, University of Leipzig Medical CenterAbstract Background Obesity is a multifactorial disease reaching pandemic proportions with increasing healthcare costs, advocating the development of better prevention and treatment strategies. Previous research indicates that the gut microbiome plays an important role in metabolic, hormonal, and neuronal cross-talk underlying eating behavior. We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT). Method This study uses a parallel arm RCT design with a 26-week intervention period. We plan to enroll 90 participants (male/diverse/female) living with overweight or obesity, defined as either a Waist-to-Hip Ratio (WHR) ≥ 0.9 (male)/0.85 (diverse, female) or a Body Mass Index (BMI) ≥ 25 kg/m2. Key inclusion criteria are 18–60 years of age and exclusion criteria are type 2 diabetes, psychiatric disease, and Magnetic Resonance Imaging (MRI) contraindications. The interventions comprise either a daily supplementary intake of 30 g soluble fiber (inulin), or weekly neurocognitive behavioral group sessions, compared to placebo (equicaloric maltodextrin). At baseline and follow-up, food decision-making is assessed utilizing task-based MRI. Secondary outcome measures include structural MRI, eating habits, lifestyle factors, personality traits, and mood. Further, we obtain fecal and blood samples to investigate gut microbiome composition and related metabolites. Discussion This study relies on expanding research suggesting that dietary prebiotics could improve gut microbiome composition, leading to beneficial effects on gut-brain signaling and higher-order cognitive functions. In parallel, neurocognitive behavioral interventions have been proposed to improve unhealthy eating habits and metabolic status. However, causal evidence on how these “bottom-up” and “top-down” processes affect food decision-making and neuronal correlates in humans is still scarce. In addition, microbiome, and gut-brain-axis-related mediating mechanisms remain unclear. The present study proposes a comprehensive approach to assess the effects of these gut-brain-related processes influencing food decision-making in overweight and obesity. Trial registration ClinicalTrials.gov NCT05353504. Retrospectively registered on 29 April 2022.https://doi.org/10.1186/s40795-024-00971-6Gut-Brain axisPrebioticsNeurocognitive behavioral interventionMicrobiomeMRIEating behavior |
| spellingShingle | Meghedi Vartanian Konrad Jakob Endres Yee Teng Lee Silke Friedrich Marie-Theres Meemken Imke Schamarek Kerstin Rohde-Zimmermann Robin Schürfeld Lina Eisenberg Anja Hilbert Frauke Beyer Michael Stumvoll Julia Sacher Arno Villringer Julia F. Christensen A. Veronica Witte Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol BMC Nutrition Gut-Brain axis Prebiotics Neurocognitive behavioral intervention Microbiome MRI Eating behavior |
| title | Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol |
| title_full | Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol |
| title_fullStr | Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol |
| title_full_unstemmed | Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol |
| title_short | Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol |
| title_sort | investigating the impact of microbiome changing interventions on food decision making mifood study protocol |
| topic | Gut-Brain axis Prebiotics Neurocognitive behavioral intervention Microbiome MRI Eating behavior |
| url | https://doi.org/10.1186/s40795-024-00971-6 |
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