Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension
Cardioplegic arrest and cardiopulmonary bypass (CP/CPB) are known to engender microvascular dysfunction in patients undergoing cardiac surgery. These effects are significantly varied by patient comorbidities including diabetes and hypertension. Both diabetes and hypertension are associated with wors...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/2/409 |
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| author | Meghamsh Kanuparthy Rishik Manthana Himanshu Kaushik Kathy Xiang Jad Hamze David Marimekala Jun Feng Frank W. Sellke |
| author_facet | Meghamsh Kanuparthy Rishik Manthana Himanshu Kaushik Kathy Xiang Jad Hamze David Marimekala Jun Feng Frank W. Sellke |
| author_sort | Meghamsh Kanuparthy |
| collection | DOAJ |
| description | Cardioplegic arrest and cardiopulmonary bypass (CP/CPB) are known to engender microvascular dysfunction in patients undergoing cardiac surgery. These effects are significantly varied by patient comorbidities including diabetes and hypertension. Both diabetes and hypertension are associated with worse outcomes after cardiac surgery, partly related to increased microvascular complications. In this review, we examine several key facets of microvascular dysfunction after CP/CPB: microvascular endothelial and vasomotor dysfunction, altered gene and protein expression, endothelial adherens junction dysfunction, and programmed cell death as they relate to diabetes and hypertension. This review examines both classical techniques, including microvessel reactivity assays, and modern multiomic approaches to characterizing these microvascular changes. |
| format | Article |
| id | doaj-art-739a9dd8dfa645b591e01cffd0199d90 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-739a9dd8dfa645b591e01cffd0199d902025-08-20T03:12:16ZengMDPI AGBiomedicines2227-90592025-02-0113240910.3390/biomedicines13020409Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and HypertensionMeghamsh Kanuparthy0Rishik Manthana1Himanshu Kaushik2Kathy Xiang3Jad Hamze4David Marimekala5Jun Feng6Frank W. Sellke7Division of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School, Brown University, Providence, RI 02903, USACardioplegic arrest and cardiopulmonary bypass (CP/CPB) are known to engender microvascular dysfunction in patients undergoing cardiac surgery. These effects are significantly varied by patient comorbidities including diabetes and hypertension. Both diabetes and hypertension are associated with worse outcomes after cardiac surgery, partly related to increased microvascular complications. In this review, we examine several key facets of microvascular dysfunction after CP/CPB: microvascular endothelial and vasomotor dysfunction, altered gene and protein expression, endothelial adherens junction dysfunction, and programmed cell death as they relate to diabetes and hypertension. This review examines both classical techniques, including microvessel reactivity assays, and modern multiomic approaches to characterizing these microvascular changes.https://www.mdpi.com/2227-9059/13/2/409microvascular dysfunctiondiabeteshypertensioncardioplegiacardiopulmonary bypass |
| spellingShingle | Meghamsh Kanuparthy Rishik Manthana Himanshu Kaushik Kathy Xiang Jad Hamze David Marimekala Jun Feng Frank W. Sellke Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension Biomedicines microvascular dysfunction diabetes hypertension cardioplegia cardiopulmonary bypass |
| title | Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension |
| title_full | Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension |
| title_fullStr | Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension |
| title_full_unstemmed | Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension |
| title_short | Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension |
| title_sort | microvascular dysfunction following cardioplegic arrest and cardiopulmonary bypass impacts of diabetes and hypertension |
| topic | microvascular dysfunction diabetes hypertension cardioplegia cardiopulmonary bypass |
| url | https://www.mdpi.com/2227-9059/13/2/409 |
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