Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer

Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer

Background/Objectives: Metastatic prostate cancer (PCa) remains a major clinical challenge with limited therapeutic options. The long non-coding RNA <i>H19</i> has been implicated in regulating cell adhesion molecules and collective migration, key features of metastatic dissemination. Th...

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Main Authors: Valeria Pecci, Melissa Borsa, Aurora Aiello, Sara De Martino, Luca Cis, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Francesco Pinto, Claudio Grassi, Carlo Gaetano, Antonella Farsetti, Simona Nanni
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Non-Coding RNA
Subjects:
long non-coding RNA
metastatic program
epigenetics
transcription regulation
Online Access:https://www.mdpi.com/2311-553X/11/3/33
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