HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State
Insulin resistance is categorized as type A or type B, depending on the etiology. HAIRAN syndrome is a subtype of type A insulin resistance. It is characterized by high insulin resistance, hyperandrogenemia, and hyperinsulinemia. Here, we present a 12-year-old girl who was lean during her first dec...
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Tehran University of Medical Sciences
2025-07-01
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| Series: | Case Reports in Clinical Practice |
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| Online Access: | https://crcp.tums.ac.ir/index.php/crcp/article/view/1033 |
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| author | Sriram Mudraje Nancy Garg Jaideep Khare Sushil Jindal |
| author_facet | Sriram Mudraje Nancy Garg Jaideep Khare Sushil Jindal |
| author_sort | Sriram Mudraje |
| collection | DOAJ |
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Insulin resistance is categorized as type A or type B, depending on the etiology. HAIRAN syndrome is a subtype of type A insulin resistance. It is characterized by high insulin resistance, hyperandrogenemia, and hyperinsulinemia. Here, we present a 12-year-old girl who was lean during her first decade of life and came with complaints of gradual-onset weight gain, darkening of her neck and limbs, and roughening of her skin. Menarche had not been attained. She had Grade 4 acanthosis nigricans, thick coarse skin, and hirsutism.
Investigations revealed raised blood glucose, elevated testosterone, elevated fasting insulin, and raised HOMA-IR. With biochemical evidence of hyperandrogenemia, insulin resistance, and the presence of acanthosis nigricans, the diagnosis of HAIR-AN syndrome was made.
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| format | Article |
| id | doaj-art-7392ba37d4844a85a3867bd487d04d06 |
| institution | DOAJ |
| issn | 2538-2683 2538-2691 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Case Reports in Clinical Practice |
| spelling | doaj-art-7392ba37d4844a85a3867bd487d04d062025-08-20T03:03:04ZengTehran University of Medical SciencesCase Reports in Clinical Practice2538-26832538-26912025-07-019610.18502/crcp.v9i6.18947HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic StateSriram Mudraje0Nancy Garg1Jaideep Khare2Sushil Jindal3Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India.Department of Endocrinology, People’s College of Medical Sciences and Research Centre, People’s University, Bhopal, India. Insulin resistance is categorized as type A or type B, depending on the etiology. HAIRAN syndrome is a subtype of type A insulin resistance. It is characterized by high insulin resistance, hyperandrogenemia, and hyperinsulinemia. Here, we present a 12-year-old girl who was lean during her first decade of life and came with complaints of gradual-onset weight gain, darkening of her neck and limbs, and roughening of her skin. Menarche had not been attained. She had Grade 4 acanthosis nigricans, thick coarse skin, and hirsutism. Investigations revealed raised blood glucose, elevated testosterone, elevated fasting insulin, and raised HOMA-IR. With biochemical evidence of hyperandrogenemia, insulin resistance, and the presence of acanthosis nigricans, the diagnosis of HAIR-AN syndrome was made. https://crcp.tums.ac.ir/index.php/crcp/article/view/1033HAIR-AN syndromeHyperinsulinemiaInsulin resistanceHyperandrogenemia |
| spellingShingle | Sriram Mudraje Nancy Garg Jaideep Khare Sushil Jindal HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State Case Reports in Clinical Practice HAIR-AN syndrome Hyperinsulinemia Insulin resistance Hyperandrogenemia |
| title | HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State |
| title_full | HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State |
| title_fullStr | HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State |
| title_full_unstemmed | HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State |
| title_short | HAIR-AN Syndrome: A Rare Cause of Hyper Insulinemic State |
| title_sort | hair an syndrome a rare cause of hyper insulinemic state |
| topic | HAIR-AN syndrome Hyperinsulinemia Insulin resistance Hyperandrogenemia |
| url | https://crcp.tums.ac.ir/index.php/crcp/article/view/1033 |
| work_keys_str_mv | AT srirammudraje hairansyndromeararecauseofhyperinsulinemicstate AT nancygarg hairansyndromeararecauseofhyperinsulinemicstate AT jaideepkhare hairansyndromeararecauseofhyperinsulinemicstate AT sushiljindal hairansyndromeararecauseofhyperinsulinemicstate |