Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma

Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma

Abstract Objective To evaluate the correlation between ATP‐binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody‐drug conjugate targeting Nectin‐4, in urothelial cancer, as only a few studies have been conducted on this topic. Patients and met...

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Main Authors: Toshiki Kijima, Atsuko Takada‐Owada, Hiroki Shimoda, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Hironori Betsunoh, Masahiro Yashi, Kazuyuki Ishida, Takao Kamai
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:BJUI Compass
Subjects:
ABC transporters
drug resistance
Enfortumab Vedotin
metastatic urothelial carcinoma
Nectin‐4
Online Access:https://doi.org/10.1002/bco2.488
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