Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow
Background: Neuroscience advances have highlighted the potential of non-invasive brain stimulation in influencing cognitive and emotional processes. Conventional stimulation methods such as electrical, magnetic, and ultrasound have been studied intensively, but little is known about the mechanical s...
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Elsevier
2025-03-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S105381192500076X |
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| author | Linghan Kong Wei Jin Yue Jiang Fuhua Yan Jun Liu Eric C. Leuthardt Guang-Zhong Yang Yuan Feng |
| author_facet | Linghan Kong Wei Jin Yue Jiang Fuhua Yan Jun Liu Eric C. Leuthardt Guang-Zhong Yang Yuan Feng |
| author_sort | Linghan Kong |
| collection | DOAJ |
| description | Background: Neuroscience advances have highlighted the potential of non-invasive brain stimulation in influencing cognitive and emotional processes. Conventional stimulation methods such as electrical, magnetic, and ultrasound have been studied intensively, but little is known about the mechanical stimulation. Objective: To investigate the effects of 40 Hz transcranial vibration stimulation (TVS) on human brain activity, specifically focusing on changes in the Amplitude of Low-Frequency Fluctuation (ALFF), fractional ALFF (fALFF) and Regional Homogeneity (ReHo) as measures of spontaneous brain activity. Additionally, this study investigates alterations in the global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow coupling, which serve as indicators of glymphatic system function. Methods: A custom-built head actuator was used to apply 40 Hz TVS to human brain. Functional magnetic resonance imaging (fMRI) were performed before and after 5 mins TVS to explore the changes in ALFF and fALFF and the coupling of global brain activity with cerebrospinal fluid flow (CSF), which is related to the glymphatic clearance. Results: Significant increases were observed in both ALFF and fALFF metrics, indicating that 40 Hz TVS effectively enhanced spontaneous brain activity. Additionally, 40 Hz TVS promoted the synchronization of overall brain activity with CSF, suggesting an improvement in glymphatic clearance processes, an effect that 30 Hz or 50 Hz TVS did not replicate. Conclusion: Non-invasive brain stimulation using TVS provided important implications for modulating brain physiology and showed prospective therapeutic benefits for neurological diseases. |
| format | Article |
| id | doaj-art-7389856283e945a791b682ed13704583 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-7389856283e945a791b682ed137045832025-02-10T04:34:14ZengElsevierNeuroImage1095-95722025-03-01308121074Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flowLinghan Kong0Wei Jin1Yue Jiang2Fuhua Yan3Jun Liu4Eric C. Leuthardt5Guang-Zhong Yang6Yuan Feng7School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China; Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China; National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, ChinaDepartment of Radiology, Ruijin Hospital, Shanghai 200025, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Neurosurgery, Washington University School of Medicine in St. Louis, Washington MO 63110, USASchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China; Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China; National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authors.School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China; Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China; National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China; Department of Radiology, Ruijin Hospital, Shanghai 200025, China; Corresponding authors.Background: Neuroscience advances have highlighted the potential of non-invasive brain stimulation in influencing cognitive and emotional processes. Conventional stimulation methods such as electrical, magnetic, and ultrasound have been studied intensively, but little is known about the mechanical stimulation. Objective: To investigate the effects of 40 Hz transcranial vibration stimulation (TVS) on human brain activity, specifically focusing on changes in the Amplitude of Low-Frequency Fluctuation (ALFF), fractional ALFF (fALFF) and Regional Homogeneity (ReHo) as measures of spontaneous brain activity. Additionally, this study investigates alterations in the global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow coupling, which serve as indicators of glymphatic system function. Methods: A custom-built head actuator was used to apply 40 Hz TVS to human brain. Functional magnetic resonance imaging (fMRI) were performed before and after 5 mins TVS to explore the changes in ALFF and fALFF and the coupling of global brain activity with cerebrospinal fluid flow (CSF), which is related to the glymphatic clearance. Results: Significant increases were observed in both ALFF and fALFF metrics, indicating that 40 Hz TVS effectively enhanced spontaneous brain activity. Additionally, 40 Hz TVS promoted the synchronization of overall brain activity with CSF, suggesting an improvement in glymphatic clearance processes, an effect that 30 Hz or 50 Hz TVS did not replicate. Conclusion: Non-invasive brain stimulation using TVS provided important implications for modulating brain physiology and showed prospective therapeutic benefits for neurological diseases.http://www.sciencedirect.com/science/article/pii/S105381192500076XVibrationSpontaneous brain activityCerebrospinal fluid flow |
| spellingShingle | Linghan Kong Wei Jin Yue Jiang Fuhua Yan Jun Liu Eric C. Leuthardt Guang-Zhong Yang Yuan Feng Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow NeuroImage Vibration Spontaneous brain activity Cerebrospinal fluid flow |
| title | Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| title_full | Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| title_fullStr | Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| title_full_unstemmed | Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| title_short | Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| title_sort | transcranial vibration stimulation at 40 hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow |
| topic | Vibration Spontaneous brain activity Cerebrospinal fluid flow |
| url | http://www.sciencedirect.com/science/article/pii/S105381192500076X |
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