Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment
As major environmental pollutants, heavy metals can enter the maternal body through various pathways during pregnancy, cross the placental barrier, and subsequently induce toxic effects in offspring. Prenatal heavy metal exposure not only indirectly impairs fetal neurodevelopment by compromising mat...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2025-03-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250108?st=article_issue |
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| author | Cheng Hong Yang Xiaobo |
| author_facet | Cheng Hong Yang Xiaobo |
| author_sort | Cheng Hong |
| collection | DOAJ |
| description | As major environmental pollutants, heavy metals can enter the maternal body through various pathways during pregnancy, cross the placental barrier, and subsequently induce toxic effects in offspring. Prenatal heavy metal exposure not only indirectly impairs fetal neurodevelopment by compromising maternal health, but also directly damages the fetal nervous system by crossing the blood-brain barrier. This can lead to neurobehavioral and cognitive impairments after birth and increase the risk of various neurological disorders. The underlying mechanisms primarily include oxidative damage, excitotoxicity, calcium ion imbalance, mitochondrial dysfunction, and epigenetic modifications. This review summarizes the effects of prenatal exposure to heavy metals, including lead, cadmium, mercury, arsenic, and manganese, on offspring neurodevelopment, and explores the underlying mechanisms, aiming to provide a reference for epidemiological and experimental research. |
| format | Article |
| id | doaj-art-73884816c3f2412f95265f72be66b00a |
| institution | DOAJ |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-73884816c3f2412f95265f72be66b00a2025-08-20T03:04:20ZzhoLanzhou University Press生物医学转化2096-89652025-03-0161505710.12287/j.issn.2096-8965.20250107Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopmentCheng Hong0Yang Xiaobo1School of Public Health, Guangxi Medical University, Nanning 530021 , Guangxi, ChinaSchool of Public Health, Guangxi Medical University, Nanning 530021 , Guangxi, ChinaAs major environmental pollutants, heavy metals can enter the maternal body through various pathways during pregnancy, cross the placental barrier, and subsequently induce toxic effects in offspring. Prenatal heavy metal exposure not only indirectly impairs fetal neurodevelopment by compromising maternal health, but also directly damages the fetal nervous system by crossing the blood-brain barrier. This can lead to neurobehavioral and cognitive impairments after birth and increase the risk of various neurological disorders. The underlying mechanisms primarily include oxidative damage, excitotoxicity, calcium ion imbalance, mitochondrial dysfunction, and epigenetic modifications. This review summarizes the effects of prenatal exposure to heavy metals, including lead, cadmium, mercury, arsenic, and manganese, on offspring neurodevelopment, and explores the underlying mechanisms, aiming to provide a reference for epidemiological and experimental research.http://swyxzh.ijournals.cn/swyxzh/article/html/20250108?st=article_issueheavy metal exposureprenatal exposureoffspringneurodevelopment |
| spellingShingle | Cheng Hong Yang Xiaobo Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment 生物医学转化 heavy metal exposure prenatal exposure offspring neurodevelopment |
| title | Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| title_full | Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| title_fullStr | Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| title_full_unstemmed | Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| title_short | Research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| title_sort | research progress on effect of prenatal heavy metal exposure on offspring neurodevelopment |
| topic | heavy metal exposure prenatal exposure offspring neurodevelopment |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250108?st=article_issue |
| work_keys_str_mv | AT chenghong researchprogressoneffectofprenatalheavymetalexposureonoffspringneurodevelopment AT yangxiaobo researchprogressoneffectofprenatalheavymetalexposureonoffspringneurodevelopment |