All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes
Aims. Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The aim of this longitudinal study was to investigate the association between impaired fasting glucose or diabetes and mortality over a 10-year period in Australian women. Me...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/2042980 |
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| author | Lelia L. F. de Abreu Kara L. Holloway Mohammadreza Mohebbi Muhammad A. Sajjad Mark A. Kotowicz Julie A. Pasco |
| author_facet | Lelia L. F. de Abreu Kara L. Holloway Mohammadreza Mohebbi Muhammad A. Sajjad Mark A. Kotowicz Julie A. Pasco |
| author_sort | Lelia L. F. de Abreu |
| collection | DOAJ |
| description | Aims. Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The aim of this longitudinal study was to investigate the association between impaired fasting glucose or diabetes and mortality over a 10-year period in Australian women. Methods. This study included 1167 women (ages 20–94 yr) enrolled in the Geelong Osteoporosis Study. Hazard ratios for all-cause mortality in diabetes, IFG, and normoglycaemia were calculated using a Cox proportional hazards model. Results. Women with diabetes were older and had higher measures of adiposity, LDL cholesterol, and triglycerides compared to the IFG and normoglycaemia groups (all p<0.001). Mortality rate was greater in women with diabetes compared to both the IFG and normoglycaemia groups (HR 1.8; 95% CI 1.3–2.7). Mortality was not different in women with IFG compared to those with normoglycaemia (HR 1.0; 95% CI 0.7–1.4). Conclusions. This study reports an association between diabetes and all-cause mortality. However, no association was detected between IFG and all-cause mortality. We also showed that mortality in Australian women with diabetes continues to be elevated and women with IFG are a valuable target for prevention of premature mortality associated with diabetes. |
| format | Article |
| id | doaj-art-73851534f78e4f90b9969e3a1b997eaa |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-73851534f78e4f90b9969e3a1b997eaa2025-02-03T05:51:38ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/20429802042980All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and DiabetesLelia L. F. de Abreu0Kara L. Holloway1Mohammadreza Mohebbi2Muhammad A. Sajjad3Mark A. Kotowicz4Julie A. Pasco5Deakin University, Geelong, VIC 3220, AustraliaDeakin University, Geelong, VIC 3220, AustraliaDeakin University, Geelong, VIC 3220, AustraliaDeakin University, Geelong, VIC 3220, AustraliaDeakin University, Geelong, VIC 3220, AustraliaDeakin University, Geelong, VIC 3220, AustraliaAims. Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The aim of this longitudinal study was to investigate the association between impaired fasting glucose or diabetes and mortality over a 10-year period in Australian women. Methods. This study included 1167 women (ages 20–94 yr) enrolled in the Geelong Osteoporosis Study. Hazard ratios for all-cause mortality in diabetes, IFG, and normoglycaemia were calculated using a Cox proportional hazards model. Results. Women with diabetes were older and had higher measures of adiposity, LDL cholesterol, and triglycerides compared to the IFG and normoglycaemia groups (all p<0.001). Mortality rate was greater in women with diabetes compared to both the IFG and normoglycaemia groups (HR 1.8; 95% CI 1.3–2.7). Mortality was not different in women with IFG compared to those with normoglycaemia (HR 1.0; 95% CI 0.7–1.4). Conclusions. This study reports an association between diabetes and all-cause mortality. However, no association was detected between IFG and all-cause mortality. We also showed that mortality in Australian women with diabetes continues to be elevated and women with IFG are a valuable target for prevention of premature mortality associated with diabetes.http://dx.doi.org/10.1155/2017/2042980 |
| spellingShingle | Lelia L. F. de Abreu Kara L. Holloway Mohammadreza Mohebbi Muhammad A. Sajjad Mark A. Kotowicz Julie A. Pasco All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes Journal of Diabetes Research |
| title | All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes |
| title_full | All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes |
| title_fullStr | All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes |
| title_full_unstemmed | All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes |
| title_short | All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes |
| title_sort | all cause mortality risk in australian women with impaired fasting glucose and diabetes |
| url | http://dx.doi.org/10.1155/2017/2042980 |
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