Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome
Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women. Women with PCOS have androgen excess as a defining feature. They also have increased insulin resistance and obesity, which are also risk factors for non-alcoholic fatty liver disease (NAFLD). However, published da...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/7/1/e000352.full |
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| author | Mohammad Maysara Asfari Muhammad Talal Sarmini Firas Baidoun Yasser Al-Khadra Srinivasan Dasarathy Arthur McCullough Yamen Ezaizi |
| author_facet | Mohammad Maysara Asfari Muhammad Talal Sarmini Firas Baidoun Yasser Al-Khadra Srinivasan Dasarathy Arthur McCullough Yamen Ezaizi |
| author_sort | Mohammad Maysara Asfari |
| collection | DOAJ |
| description | Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women. Women with PCOS have androgen excess as a defining feature. They also have increased insulin resistance and obesity, which are also risk factors for non-alcoholic fatty liver disease (NAFLD). However, published data regarding PCOS as independent risk factor for NAFLD remain controversial. Therefore, we conducted this study to evaluate the association between PCOS and NAFLD using a large national database.Methods We identified adult female patients (≥18 years) with PCOS using the National Inpatient Sample database between 2002 and 2014. The control group included patients who did not have a diagnosis of PCOS. Multivariate logistic regression analysis was performed to study the association of NAFLD with PCOS.Results Out of a total of 50 785 354 women, 77 415 (0.15%) had PCOS. These patients were younger (32.7 vs 54.8; p<0.001) and more likely to be obese (29.4% vs 8.6%; p<0.001) compared with non-PCOS patients. However, the PCOS group had less hypertension (23.2% vs 39.8%), dyslipidaemia (12% vs 17.8%) and diabetes mellitus (18.1% vs 18.3%) (p<0.001 for all). Using multivariate logistic regression, patients with PCOS had significantly higher rate of NAFLD (OR 4.30, 95% CI 4.11 to 4.50, p<0.001).Conclusion Our study showed that patients with PCOS have four times higher risk of developing NAFLD compared with women without PCOS. Further studies are needed to assess if specific PCOS treatments can affect NAFLD progression. |
| format | Article |
| id | doaj-art-7380afc4b1d5420da23699af4a97a6cf |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-7380afc4b1d5420da23699af4a97a6cf2024-12-14T17:00:09ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742020-12-017110.1136/bmjgast-2019-000352Association of non-alcoholic fatty liver disease and polycystic ovarian syndromeMohammad Maysara Asfari0Muhammad Talal Sarmini1Firas Baidoun2Yasser Al-Khadra3Srinivasan Dasarathy4Arthur McCullough5Yamen Ezaizi6Gastroenterology and Hepatology, Medical College of Georgia, Augusta University, Augusta, Georgia, USAGastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USAInternal Medicine, Cleveland Clinic, Cleveland, Ohio, USAInternal Medicine, Cleveland Clinic, Cleveland, Ohio, USAGastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USAGastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USAGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USABackground Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women. Women with PCOS have androgen excess as a defining feature. They also have increased insulin resistance and obesity, which are also risk factors for non-alcoholic fatty liver disease (NAFLD). However, published data regarding PCOS as independent risk factor for NAFLD remain controversial. Therefore, we conducted this study to evaluate the association between PCOS and NAFLD using a large national database.Methods We identified adult female patients (≥18 years) with PCOS using the National Inpatient Sample database between 2002 and 2014. The control group included patients who did not have a diagnosis of PCOS. Multivariate logistic regression analysis was performed to study the association of NAFLD with PCOS.Results Out of a total of 50 785 354 women, 77 415 (0.15%) had PCOS. These patients were younger (32.7 vs 54.8; p<0.001) and more likely to be obese (29.4% vs 8.6%; p<0.001) compared with non-PCOS patients. However, the PCOS group had less hypertension (23.2% vs 39.8%), dyslipidaemia (12% vs 17.8%) and diabetes mellitus (18.1% vs 18.3%) (p<0.001 for all). Using multivariate logistic regression, patients with PCOS had significantly higher rate of NAFLD (OR 4.30, 95% CI 4.11 to 4.50, p<0.001).Conclusion Our study showed that patients with PCOS have four times higher risk of developing NAFLD compared with women without PCOS. Further studies are needed to assess if specific PCOS treatments can affect NAFLD progression.https://bmjopengastro.bmj.com/content/7/1/e000352.full |
| spellingShingle | Mohammad Maysara Asfari Muhammad Talal Sarmini Firas Baidoun Yasser Al-Khadra Srinivasan Dasarathy Arthur McCullough Yamen Ezaizi Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome BMJ Open Gastroenterology |
| title | Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome |
| title_full | Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome |
| title_fullStr | Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome |
| title_full_unstemmed | Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome |
| title_short | Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome |
| title_sort | association of non alcoholic fatty liver disease and polycystic ovarian syndrome |
| url | https://bmjopengastro.bmj.com/content/7/1/e000352.full |
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