Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs
Abstract Mitogen-activated protein kinase 14 (MAPK14) has a fundamental role in the development of different inflammatory and neurodegenerative disorders. However, its roles in the pathoetiology of migraine are not clear. The current case-control study focused on expression analysis of MAPK14 and re...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-91943-8 |
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| author | Fatemeh Ensafi Talemi Bashdar Mahmud Hussen Fatemeh Keshmir Abolfazl Movafagh Parisa Sarabi Mohammad Rahmanian Arezou Sayad Soudeh Ghafouri-Fard |
| author_facet | Fatemeh Ensafi Talemi Bashdar Mahmud Hussen Fatemeh Keshmir Abolfazl Movafagh Parisa Sarabi Mohammad Rahmanian Arezou Sayad Soudeh Ghafouri-Fard |
| author_sort | Fatemeh Ensafi Talemi |
| collection | DOAJ |
| description | Abstract Mitogen-activated protein kinase 14 (MAPK14) has a fundamental role in the development of different inflammatory and neurodegenerative disorders. However, its roles in the pathoetiology of migraine are not clear. The current case-control study focused on expression analysis of MAPK14 and related long non-coding RNAs (lncRNAs) in the circulation of migraineurs compared with healthy controls. Data showed remarkable elevation of expression levels of MAPK14, HLA Complex Group 11 (HCG11), zinc ribbon domain-containing 1-antisense 1 (ZNRD1-AS1), RAD51 antisense RNA 1 (RAD51-AS1) and long noncoding RNA-activated by DNA damage (NORAD) in both groups of migraineurs (with aura and without aura) compared with controls. The accuracy of expression levels of MAPK14, HCG11, ZNRD1-AS1, RAD51-AS1 and NORAD for differentiating migraineurs from controls was 85.71%, 81.56%, 85.11%, 77.8% and 94.33%, respectively. Thus, MAPK14 and its related lncRNAs are putative markers for migraine and might participate in the pathogenesis of this neurologic condition. |
| format | Article |
| id | doaj-art-7380304a937a45deb0fa5e497ea37c3b |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-7380304a937a45deb0fa5e497ea37c3b2025-08-20T03:04:12ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-91943-8Up-regulation of MAPK14-related lncRNAs in the circulation of migraineursFatemeh Ensafi Talemi0Bashdar Mahmud Hussen1Fatemeh Keshmir2Abolfazl Movafagh3Parisa Sarabi4Mohammad Rahmanian5Arezou Sayad6Soudeh Ghafouri-Fard7Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical UniversityPhytochemistry Research Centre, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesPhytochemistry Research Centre, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesAbstract Mitogen-activated protein kinase 14 (MAPK14) has a fundamental role in the development of different inflammatory and neurodegenerative disorders. However, its roles in the pathoetiology of migraine are not clear. The current case-control study focused on expression analysis of MAPK14 and related long non-coding RNAs (lncRNAs) in the circulation of migraineurs compared with healthy controls. Data showed remarkable elevation of expression levels of MAPK14, HLA Complex Group 11 (HCG11), zinc ribbon domain-containing 1-antisense 1 (ZNRD1-AS1), RAD51 antisense RNA 1 (RAD51-AS1) and long noncoding RNA-activated by DNA damage (NORAD) in both groups of migraineurs (with aura and without aura) compared with controls. The accuracy of expression levels of MAPK14, HCG11, ZNRD1-AS1, RAD51-AS1 and NORAD for differentiating migraineurs from controls was 85.71%, 81.56%, 85.11%, 77.8% and 94.33%, respectively. Thus, MAPK14 and its related lncRNAs are putative markers for migraine and might participate in the pathogenesis of this neurologic condition.https://doi.org/10.1038/s41598-025-91943-8MigraineMAPK14LncRNA |
| spellingShingle | Fatemeh Ensafi Talemi Bashdar Mahmud Hussen Fatemeh Keshmir Abolfazl Movafagh Parisa Sarabi Mohammad Rahmanian Arezou Sayad Soudeh Ghafouri-Fard Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs Scientific Reports Migraine MAPK14 LncRNA |
| title | Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs |
| title_full | Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs |
| title_fullStr | Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs |
| title_full_unstemmed | Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs |
| title_short | Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs |
| title_sort | up regulation of mapk14 related lncrnas in the circulation of migraineurs |
| topic | Migraine MAPK14 LncRNA |
| url | https://doi.org/10.1038/s41598-025-91943-8 |
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