Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers
Quorum sensing (QS) is a widely conserved cell-cell communication mechanism through which bacterial cells control physiological functions and pathogenesis. Additionally, nucleotide second messengers (NSMs) have been shown to regulate diverse bacterial functions. Acinetobacter baumannii is now a subs...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037025001928 |
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| author | Binbin Cui Ganjin Peng Liu-En Wang Yinyue Deng |
| author_facet | Binbin Cui Ganjin Peng Liu-En Wang Yinyue Deng |
| author_sort | Binbin Cui |
| collection | DOAJ |
| description | Quorum sensing (QS) is a widely conserved cell-cell communication mechanism through which bacterial cells control physiological functions and pathogenesis. Additionally, nucleotide second messengers (NSMs) have been shown to regulate diverse bacterial functions. Acinetobacter baumannii is now a substantial threat and a considerable challenge worldwide, and recent research indicates that A. baumannii not only utilizes QS systems but also employs NSMs to regulate phenotypes and virulence. In this article, we review the research progress of QS systems and NSMs of A. baumannii, and explore the prospects of utilizing these signaling systems as targets for the development of novel antibacterial agents. |
| format | Article |
| id | doaj-art-737f818b4f1747ada17d4d137fa0b987 |
| institution | DOAJ |
| issn | 2001-0370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj-art-737f818b4f1747ada17d4d137fa0b9872025-08-20T03:21:51ZengElsevierComputational and Structural Biotechnology Journal2001-03702025-01-01272168217510.1016/j.csbj.2025.05.032Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengersBinbin Cui0Ganjin Peng1Liu-En Wang2Yinyue Deng3Pharmacy Department, Ningbo Medical Center Lihuili Hospital, Ningbo 315046, China; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China; Corresponding author.Quorum sensing (QS) is a widely conserved cell-cell communication mechanism through which bacterial cells control physiological functions and pathogenesis. Additionally, nucleotide second messengers (NSMs) have been shown to regulate diverse bacterial functions. Acinetobacter baumannii is now a substantial threat and a considerable challenge worldwide, and recent research indicates that A. baumannii not only utilizes QS systems but also employs NSMs to regulate phenotypes and virulence. In this article, we review the research progress of QS systems and NSMs of A. baumannii, and explore the prospects of utilizing these signaling systems as targets for the development of novel antibacterial agents.http://www.sciencedirect.com/science/article/pii/S2001037025001928Quorum sensingNucleotide second messengersAcinetobacter baumanniiPathogenicity |
| spellingShingle | Binbin Cui Ganjin Peng Liu-En Wang Yinyue Deng Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers Computational and Structural Biotechnology Journal Quorum sensing Nucleotide second messengers Acinetobacter baumannii Pathogenicity |
| title | Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers |
| title_full | Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers |
| title_fullStr | Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers |
| title_full_unstemmed | Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers |
| title_short | Signaling in Acinetobacter baumannii: Quorum sensing and nucleotide second messengers |
| title_sort | signaling in acinetobacter baumannii quorum sensing and nucleotide second messengers |
| topic | Quorum sensing Nucleotide second messengers Acinetobacter baumannii Pathogenicity |
| url | http://www.sciencedirect.com/science/article/pii/S2001037025001928 |
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