A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer

A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer

Breast cancer is the most prevalent neoplasm in women. ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the primary driver of genetic alteration in luminal...

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Bibliographic Details
Main Authors: Amir Mahdi Khamaneh, Davoud Jafari-Gharabaghlou, Khalil Ansarin, Pouya Pazooki, Zahra Akbarpour, Behrooz Naghili, Nosratollah Zarghami
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Oncology Reviews
Subjects:
cell cycle
luminal breast cancer
chromosomal instability
copy number variation
therapeutic strategy
Online Access:https://www.frontiersin.org/articles/10.3389/or.2025.1516409/full
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