A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer
Breast cancer is the most prevalent neoplasm in women. ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the primary driver of genetic alteration in luminal...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/or.2025.1516409/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856593393942528 |
|---|---|
| author | Amir Mahdi Khamaneh Davoud Jafari-Gharabaghlou Khalil Ansarin Khalil Ansarin Khalil Ansarin Pouya Pazooki Zahra Akbarpour Behrooz Naghili Behrooz Naghili Nosratollah Zarghami Nosratollah Zarghami |
| author_facet | Amir Mahdi Khamaneh Davoud Jafari-Gharabaghlou Khalil Ansarin Khalil Ansarin Khalil Ansarin Pouya Pazooki Zahra Akbarpour Behrooz Naghili Behrooz Naghili Nosratollah Zarghami Nosratollah Zarghami |
| author_sort | Amir Mahdi Khamaneh |
| collection | DOAJ |
| description | Breast cancer is the most prevalent neoplasm in women. ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the primary driver of genetic alteration in luminal breast tumors. Genomic instability refers to the increased tendency of cancer cells to accumulate genomic alterations during cell proliferation. The cell cycle check-point response to constant and stable genomic alterations in tumor cells drives this process. The impact of CNV patterns and aneuploidies in cell cycle and proliferation perturbation has recently been highlighted by scientists in Luminal breast tumors. The impact of chromosomal instability on cancer therapy and prognosis is not a new concept. Still, the degree of emerging genomic instability leads to prognosis alteration following cell cycle deregulation by chromosomal instability could be predicted by CNVs-based reclassification of breast tumors. In this review, we try to explain the effect of CIN in the cell cycle that ended with genomic instability and altered prognosis and the impact of CIN in decision-making for a therapy strategy for patients with luminal breast cancer. |
| format | Article |
| id | doaj-art-737e5e1ebd68448184f7f10f9903bdda |
| institution | Kabale University |
| issn | 1970-5557 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj-art-737e5e1ebd68448184f7f10f9903bdda2025-02-12T07:25:49ZengFrontiers Media S.A.Oncology Reviews1970-55572025-02-011910.3389/or.2025.15164091516409A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancerAmir Mahdi Khamaneh0Davoud Jafari-Gharabaghlou1Khalil Ansarin2Khalil Ansarin3Khalil Ansarin4Pouya Pazooki5Zahra Akbarpour6Behrooz Naghili7Behrooz Naghili8Nosratollah Zarghami9Nosratollah Zarghami10Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz, IranDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranRahat Breath and Sleep Research Center, Tabriz University of Medical Science, Tabriz, IranCellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranRahat Breath and Sleep Research Center, Tabriz University of Medical Science, Tabriz, IranDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz, IranDepartment of Medical Biochemistry, Faculty of Medicine, Istanbul Aydin University, Istanbul, TürkiyeBreast cancer is the most prevalent neoplasm in women. ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the primary driver of genetic alteration in luminal breast tumors. Genomic instability refers to the increased tendency of cancer cells to accumulate genomic alterations during cell proliferation. The cell cycle check-point response to constant and stable genomic alterations in tumor cells drives this process. The impact of CNV patterns and aneuploidies in cell cycle and proliferation perturbation has recently been highlighted by scientists in Luminal breast tumors. The impact of chromosomal instability on cancer therapy and prognosis is not a new concept. Still, the degree of emerging genomic instability leads to prognosis alteration following cell cycle deregulation by chromosomal instability could be predicted by CNVs-based reclassification of breast tumors. In this review, we try to explain the effect of CIN in the cell cycle that ended with genomic instability and altered prognosis and the impact of CIN in decision-making for a therapy strategy for patients with luminal breast cancer.https://www.frontiersin.org/articles/10.3389/or.2025.1516409/fullcell cycleluminal breast cancerchromosomal instabilitycopy number variationtherapeutic strategy |
| spellingShingle | Amir Mahdi Khamaneh Davoud Jafari-Gharabaghlou Khalil Ansarin Khalil Ansarin Khalil Ansarin Pouya Pazooki Zahra Akbarpour Behrooz Naghili Behrooz Naghili Nosratollah Zarghami Nosratollah Zarghami A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer Oncology Reviews cell cycle luminal breast cancer chromosomal instability copy number variation therapeutic strategy |
| title | A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer |
| title_full | A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer |
| title_fullStr | A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer |
| title_full_unstemmed | A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer |
| title_short | A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer |
| title_sort | new insight into the impact of copy number variations on cell cycle deregulation of luminal type breast cancer |
| topic | cell cycle luminal breast cancer chromosomal instability copy number variation therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/or.2025.1516409/full |
| work_keys_str_mv | AT amirmahdikhamaneh anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT davoudjafarigharabaghlou anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT pouyapazooki anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT zahraakbarpour anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT behrooznaghili anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT behrooznaghili anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT nosratollahzarghami anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT nosratollahzarghami anewinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT amirmahdikhamaneh newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT davoudjafarigharabaghlou newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT khalilansarin newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT pouyapazooki newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT zahraakbarpour newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT behrooznaghili newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT behrooznaghili newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT nosratollahzarghami newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer AT nosratollahzarghami newinsightintotheimpactofcopynumbervariationsoncellcyclederegulationofluminaltypebreastcancer |