ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server

The suitable computation of accurate atomic charges for the GROMACS topology *.itp files of small molecules, generated in the PRODRG server, has been a tricky task nowadays because it does not calculate atomic charges using an ab initio method. Usually additional steps of structure optimization and...

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Main Authors: Diogo de Jesus Medeiros, Wilian Augusto Cortopassi, Tanos Celmar Costa França, André Silva Pimentel
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/803151
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author Diogo de Jesus Medeiros
Wilian Augusto Cortopassi
Tanos Celmar Costa França
André Silva Pimentel
author_facet Diogo de Jesus Medeiros
Wilian Augusto Cortopassi
Tanos Celmar Costa França
André Silva Pimentel
author_sort Diogo de Jesus Medeiros
collection DOAJ
description The suitable computation of accurate atomic charges for the GROMACS topology *.itp files of small molecules, generated in the PRODRG server, has been a tricky task nowadays because it does not calculate atomic charges using an ab initio method. Usually additional steps of structure optimization and charges calculation, followed by a tedious manual replacement of atomic charges in the *.itp file, are needed. In order to assist this task, we report here the ITP Adjuster 1.0, a utility program developed to perform the replacement of the PRODRG charges in the *.itp files of small molecules by ab initio charges.
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series Journal of Chemistry
spelling doaj-art-737d3815a0af409eb07986dcd0967fec2025-08-20T02:06:19ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/803151803151ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG ServerDiogo de Jesus Medeiros0Wilian Augusto Cortopassi1Tanos Celmar Costa França2André Silva Pimentel3Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rua Marquês de São Vicente 225, Gávea, 22453-900 Rio de Janeiro, RJ, BrazilDepartment of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rua Marquês de São Vicente 225, Gávea, 22453-900 Rio de Janeiro, RJ, BrazilLaboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Military Institute of Engineering, Praça General Tibúrcio, 80, Urca, 22290-270 Rio de Janeiro, RJ, BrazilDepartment of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rua Marquês de São Vicente 225, Gávea, 22453-900 Rio de Janeiro, RJ, BrazilThe suitable computation of accurate atomic charges for the GROMACS topology *.itp files of small molecules, generated in the PRODRG server, has been a tricky task nowadays because it does not calculate atomic charges using an ab initio method. Usually additional steps of structure optimization and charges calculation, followed by a tedious manual replacement of atomic charges in the *.itp file, are needed. In order to assist this task, we report here the ITP Adjuster 1.0, a utility program developed to perform the replacement of the PRODRG charges in the *.itp files of small molecules by ab initio charges.http://dx.doi.org/10.1155/2013/803151
spellingShingle Diogo de Jesus Medeiros
Wilian Augusto Cortopassi
Tanos Celmar Costa França
André Silva Pimentel
ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
Journal of Chemistry
title ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
title_full ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
title_fullStr ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
title_full_unstemmed ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
title_short ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
title_sort itp adjuster 1 0 a new utility program to adjust charges in the topology files generated by the prodrg server
url http://dx.doi.org/10.1155/2013/803151
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