Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Impaired glucose regulation is increasingly recognised in amyotrophic lateral sclerosis (ALS), yet the precise mechanisms remain unclear. Here, we investigated energy balance and glucose control in TAR DNA-binding protein 43 (TDP-43)Q331K mice, a model of ALS, at both the early and late symptomatic...

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Bibliographic Details
Main Authors: Tanya S. McDonald, Cedric S. Cui, Titaya Lerskiatiphanich, Jianina Marallag, John D. Lee
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Amyotrophic lateral sclerosis
Glucagon
Glucose tolerance
Insulin
Metabolic rate
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402500862X
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