Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology
The symptoms of restless legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria. Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time of day, resembling an above-threshold state periodically followed by a below-...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2024-12-01
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| Series: | Sleep Science |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1782176 |
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| author | Celia Garcia-Malo Irene Cano-Pumarega Andrea Castro-Villacañas-Farzamnia Sara Boi |
| author_facet | Celia Garcia-Malo Irene Cano-Pumarega Andrea Castro-Villacañas-Farzamnia Sara Boi |
| author_sort | Celia Garcia-Malo |
| collection | DOAJ |
| description | The symptoms of restless legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria. Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time of day, resembling an above-threshold state periodically followed by a below-threshold state. Although the circadian clock is crucial in the clinical features of RLS, research assessing the ultimate drivers of circadian rhythmicity is still very limited. In the present review, we show current evidence on circadian variations of neurotransmitters involved in the pathophysiology of RLS (systemic iron metabolism, brain iron homeostasis, adenosine, dopamine, glutamate, and endogenous opioids). Secondly, an overview of available therapies for RLS is presented, including information on current recommendations for symptomatic treatments in RLS. |
| format | Article |
| id | doaj-art-7379934d4f764b978e15bac2f0927b0d |
| institution | DOAJ |
| issn | 1984-0659 1984-0063 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj-art-7379934d4f764b978e15bac2f0927b0d2025-08-20T02:49:09ZengThieme Revinter Publicações Ltda.Sleep Science1984-06591984-00632024-12-011704e470e47510.1055/s-0044-1782176Circadian Pattern in Restless Legs Syndrome: Implications for Treatment PosologyCelia Garcia-Malo0https://orcid.org/0000-0002-4690-7965Irene Cano-Pumarega1Andrea Castro-Villacañas-Farzamnia2Sara Boi3Neurology Department, Centro Integral de Sueño y Neurociencias (CISNe), Madrid, SpainNeurology Department, Centro Integral de Sueño y Neurociencias (CISNe), Madrid, SpainNeurology Department, Centro Integral de Sueño y Neurociencias (CISNe), Madrid, SpainNeurology Department, Centro Integral de Sueño y Neurociencias (CISNe), Madrid, SpainThe symptoms of restless legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria. Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time of day, resembling an above-threshold state periodically followed by a below-threshold state. Although the circadian clock is crucial in the clinical features of RLS, research assessing the ultimate drivers of circadian rhythmicity is still very limited. In the present review, we show current evidence on circadian variations of neurotransmitters involved in the pathophysiology of RLS (systemic iron metabolism, brain iron homeostasis, adenosine, dopamine, glutamate, and endogenous opioids). Secondly, an overview of available therapies for RLS is presented, including information on current recommendations for symptomatic treatments in RLS.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1782176restless legs syndromecircadian patternRLS symptomsRLS symptomatic treatment |
| spellingShingle | Celia Garcia-Malo Irene Cano-Pumarega Andrea Castro-Villacañas-Farzamnia Sara Boi Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology Sleep Science restless legs syndrome circadian pattern RLS symptoms RLS symptomatic treatment |
| title | Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology |
| title_full | Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology |
| title_fullStr | Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology |
| title_full_unstemmed | Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology |
| title_short | Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology |
| title_sort | circadian pattern in restless legs syndrome implications for treatment posology |
| topic | restless legs syndrome circadian pattern RLS symptoms RLS symptomatic treatment |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1782176 |
| work_keys_str_mv | AT celiagarciamalo circadianpatterninrestlesslegssyndromeimplicationsfortreatmentposology AT irenecanopumarega circadianpatterninrestlesslegssyndromeimplicationsfortreatmentposology AT andreacastrovillacanasfarzamnia circadianpatterninrestlesslegssyndromeimplicationsfortreatmentposology AT saraboi circadianpatterninrestlesslegssyndromeimplicationsfortreatmentposology |