Relationship between expression of CEP55 in colorectal cancer tissues and clinicopathological characteristics and prognosis
[Objectives] To investigate the expression of centrosome associated protein 55 (CEP55) in colorectal cancer tissues and its relationship with clinicopathological characteristics and prognosis. [Methods] One hundred and twenty-six patients who were diagnosed with colorectal cancer and underwent surgi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Colorectal & Anal Surgery
2024-04-01
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| Series: | 结直肠肛门外科 |
| Subjects: | |
| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=143&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC2%E6%9C%9F |
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| Summary: | [Objectives] To investigate the expression of centrosome associated protein 55 (CEP55) in colorectal cancer tissues and its relationship with clinicopathological characteristics and prognosis. [Methods] One hundred and twenty-six patients who were diagnosed with colorectal cancer and underwent surgical treatment in Tangshan Hospital of Traditional Chinese Medicine from August 2017 to August 2020 were recruited. Samples of colorectal cancer tissues and paracancerous tissues (>2 cm away from cancer tissues) removed during operation were 126 cases each. The expression of CEP55 in colorectal cancer tissues and paracancerous tissues was detected by qPCR and immunohistochemical experiments, and the relationship between the expression of CEP55 in colorectal cancer tissues and clinicopathological characteristics was analyzed. Kaplan-Meier method was used to draw the survival curve, and the relationship between the expression of CEP55 in colorectal cancer tissues and the 3-year overall survival rate of patients was analyzed. [Results] The expression of CEP55 mRNA in colorectal cancer tissues was higher than that in paracancerous tissues [(1.0±0.2) vs. (0.6±0.1)], and the difference was statistically significant (P<0.001). Immunohistochemical results showed that the expression of CEP55 in colorectal cancer tissues was higher than that in paracancerous tissues, and the proportion of CEP55 high expression in colorectal cancer tissues was higher than that in paracancerous tissues (P<0.001). The expression of CEP55 in colorectal cancer tissues was associated with TNM stage (P<0.05), but not with gender, age, degree of tumor differentiation, maximum tumor diameter, lymph node metastasis, tumor location, or depth of tumor invasion (P>0.05). The expression score of CEP55 in patients with stage Ⅲ+Ⅳ colorectal cancer was higher than in patients with stage Ⅰ+Ⅱ colorectal cancer (P<0.001). The 3-year overall survival rate of colorectal cancer patients with high CEP55 expression was lower than that of colorectal cancer patients with low CEP55 expression (70.3% vs. 88.6%), and the difference was statistically significant (Log-rank χ2＝4.715, P＝0.031). [Conclusion] CEP55 is highly expressed in colorectal cancer tissues and is associated with TNM stage, which may serve as a potential prognostic biomarker for colorectal cancer. |
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| ISSN: | 1674-0491 |