Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study
Background: Oral squamous cell carcinoma (OSCC) accounts for 84–97 % of all cases of oral cancer. Oral submucous and leukoplakia are examples of potentially malignant disorders (PMDs) that are signs of the preclinical stage of oral cancerCD44 (Cluster of differentiation) is a cell surface glycoprote...
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024003583 |
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| author | Tharani V Nandhini Gunasekaran Rajkumar Krishnan Swaathi R Vasanthi V |
| author_facet | Tharani V Nandhini Gunasekaran Rajkumar Krishnan Swaathi R Vasanthi V |
| author_sort | Tharani V |
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| description | Background: Oral squamous cell carcinoma (OSCC) accounts for 84–97 % of all cases of oral cancer. Oral submucous and leukoplakia are examples of potentially malignant disorders (PMDs) that are signs of the preclinical stage of oral cancerCD44 (Cluster of differentiation) is a cell surface glycoprotein that serves as a Cancer Stem Cell marker. Aim: The purpose of the study was to look at the presence of CD44 immunohistochemically in oral epithelial dysplasia, oral submucous fibrosis, and OSCC and how it influences a patient's prognosis. Materials and methods: In this retrospective study, the expression of CD44 were evaluated in 60 paraffin –embedded specimens (20 OSCC, 20 Dysplasia, 20 OSMF). This study was evaluated by spss 21. Differences in the mean number of CD 44-positive cells per field among epithelial dysplasia, oral submucous fibrosis and squamous cell carcinomas were assessed using one-way ANOVA and comparison between the groups were analysed by using Bonferroni post hoc test. Statistical significance was at P < 0.05. Results: On comparing the CD44 immuno-expression, the highest expression was seen in OSCC followed by dysplasia and OSMF. The OSCC group had a high mean total score of 7.90, followed by dysplasia at 5.40 and OSMF at 5.05. Conclusion: According to our research, there was a discernible pattern of elevated CD44 expression in OSCC relative to OSMF and dysplasia. These findings set the premise for further research to better outline the role of CD44 in the diagnosis of OSCC. |
| format | Article |
| id | doaj-art-737021f0982541619ec4c295a0d844ec |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
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| series | Oral Oncology Reports |
| spelling | doaj-art-737021f0982541619ec4c295a0d844ec2025-01-09T06:16:35ZengElsevierOral Oncology Reports2772-90602024-06-0110100512Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical studyTharani V0Nandhini Gunasekaran1Rajkumar Krishnan2Swaathi R3Vasanthi V4Department of Oral Pathology & Microbiology, Coorg Institute of Dental Science, Karnataka, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, India; Corresponding author. Department of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, 600089, Tamil Nadu, India.Department of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaPrivate Practice, Chennai, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaBackground: Oral squamous cell carcinoma (OSCC) accounts for 84–97 % of all cases of oral cancer. Oral submucous and leukoplakia are examples of potentially malignant disorders (PMDs) that are signs of the preclinical stage of oral cancerCD44 (Cluster of differentiation) is a cell surface glycoprotein that serves as a Cancer Stem Cell marker. Aim: The purpose of the study was to look at the presence of CD44 immunohistochemically in oral epithelial dysplasia, oral submucous fibrosis, and OSCC and how it influences a patient's prognosis. Materials and methods: In this retrospective study, the expression of CD44 were evaluated in 60 paraffin –embedded specimens (20 OSCC, 20 Dysplasia, 20 OSMF). This study was evaluated by spss 21. Differences in the mean number of CD 44-positive cells per field among epithelial dysplasia, oral submucous fibrosis and squamous cell carcinomas were assessed using one-way ANOVA and comparison between the groups were analysed by using Bonferroni post hoc test. Statistical significance was at P < 0.05. Results: On comparing the CD44 immuno-expression, the highest expression was seen in OSCC followed by dysplasia and OSMF. The OSCC group had a high mean total score of 7.90, followed by dysplasia at 5.40 and OSMF at 5.05. Conclusion: According to our research, there was a discernible pattern of elevated CD44 expression in OSCC relative to OSMF and dysplasia. These findings set the premise for further research to better outline the role of CD44 in the diagnosis of OSCC.http://www.sciencedirect.com/science/article/pii/S2772906024003583CD44DysplasiaImmunohistochemistryOSCC |
| spellingShingle | Tharani V Nandhini Gunasekaran Rajkumar Krishnan Swaathi R Vasanthi V Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study Oral Oncology Reports CD44 Dysplasia Immunohistochemistry OSCC |
| title | Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study |
| title_full | Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study |
| title_fullStr | Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study |
| title_full_unstemmed | Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study |
| title_short | Evaluating the role of CD44 in oral squamous cell carcinoma and potentially malignant disorders – An immunohistochemical study |
| title_sort | evaluating the role of cd44 in oral squamous cell carcinoma and potentially malignant disorders an immunohistochemical study |
| topic | CD44 Dysplasia Immunohistochemistry OSCC |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024003583 |
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