Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis
BackgroundThe association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1550683/full |
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| author | Tribikram Debata Amrita Swain Amrita Swain Soumya Ranjan Jena Soumya Ranjan Jena Surya Narayan Das Niranjan Mishra Luna Samanta Luna Samanta |
| author_facet | Tribikram Debata Amrita Swain Amrita Swain Soumya Ranjan Jena Soumya Ranjan Jena Surya Narayan Das Niranjan Mishra Luna Samanta Luna Samanta |
| author_sort | Tribikram Debata |
| collection | DOAJ |
| description | BackgroundThe association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the influence of VDR gene variants on the development of tobacco-related oral cancer, emphasizing genetic underpinnings of individual vulnerability and possible tailored preventative approaches.Materials and methodsThe search strategy for this systematic review and meta-analysis was devised to comprehensively identify relevant studies from diverse sources. The investigation included three primary components: the VDR gene, oral cancer, and tobacco. The data from the papers included in the study were independently retrieved by two reviewers. The incidence was evaluated as an odds ratio (OR) with 95% confidence interval (95% CI) using SPSS software.ResultsA preliminary search of biomedical electronic research databases (PubMed, Web of Science, Scopus, Embase, and the Cochrane Library) yielded 60,345 papers. After multi-phase exclusions, five studies met the inclusion criteria. The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. The CYP24A1 (rs2296241) heterozygote genotype significantly reduces oral cancer risk (OR = 0.281, P = 0.00001). Variants rs1544410 and rs2228570 influence oral health outcomes. The rs2239185 TT (OR = 2.68, P = 0.009) and rs7975232 CC (OR = 2.25, P = 0.026) increase oral lichen planus risk. Older age is significantly linked to OSCC risk (P = 0.001).ConclusionThis research underscores the role of VDR gene variants in tobacco-related oral cancer. Further studies are essential to validate findings and explore underlying mechanisms.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42024587292, identifier: CRD42024587292. |
| format | Article |
| id | doaj-art-736fdd0640ee4887bbd4fe786fae77be |
| institution | OA Journals |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-736fdd0640ee4887bbd4fe786fae77be2025-08-20T02:20:00ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-04-01610.3389/froh.2025.15506831550683Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysisTribikram Debata0Amrita Swain1Amrita Swain2Soumya Ranjan Jena3Soumya Ranjan Jena4Surya Narayan Das5Niranjan Mishra6Luna Samanta7Luna Samanta8Department of Oral and Maxillofacial Pathology, SCB Dental College and Hospital, Cuttack, Odisha, IndiaDepartment of Oral and Maxillofacial Pathology, SCB Dental College and Hospital, Cuttack, Odisha, IndiaRedox Biology and Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack, IndiaRedox Biology and Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack, IndiaCentre of Excellence for Environment & Public Health, Ravenshaw University, Cuttack, IndiaDepartment of Oral and Maxillofacial Pathology, SCB Dental College and Hospital, Cuttack, Odisha, IndiaDepartment of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, IndiaRedox Biology and Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack, IndiaCentre of Excellence for Environment & Public Health, Ravenshaw University, Cuttack, IndiaBackgroundThe association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the influence of VDR gene variants on the development of tobacco-related oral cancer, emphasizing genetic underpinnings of individual vulnerability and possible tailored preventative approaches.Materials and methodsThe search strategy for this systematic review and meta-analysis was devised to comprehensively identify relevant studies from diverse sources. The investigation included three primary components: the VDR gene, oral cancer, and tobacco. The data from the papers included in the study were independently retrieved by two reviewers. The incidence was evaluated as an odds ratio (OR) with 95% confidence interval (95% CI) using SPSS software.ResultsA preliminary search of biomedical electronic research databases (PubMed, Web of Science, Scopus, Embase, and the Cochrane Library) yielded 60,345 papers. After multi-phase exclusions, five studies met the inclusion criteria. The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. The CYP24A1 (rs2296241) heterozygote genotype significantly reduces oral cancer risk (OR = 0.281, P = 0.00001). Variants rs1544410 and rs2228570 influence oral health outcomes. The rs2239185 TT (OR = 2.68, P = 0.009) and rs7975232 CC (OR = 2.25, P = 0.026) increase oral lichen planus risk. Older age is significantly linked to OSCC risk (P = 0.001).ConclusionThis research underscores the role of VDR gene variants in tobacco-related oral cancer. Further studies are essential to validate findings and explore underlying mechanisms.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42024587292, identifier: CRD42024587292.https://www.frontiersin.org/articles/10.3389/froh.2025.1550683/fullVDR genevitamin Dtobaccooral canceroral lichen planus |
| spellingShingle | Tribikram Debata Amrita Swain Amrita Swain Soumya Ranjan Jena Soumya Ranjan Jena Surya Narayan Das Niranjan Mishra Luna Samanta Luna Samanta Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis Frontiers in Oral Health VDR gene vitamin D tobacco oral cancer oral lichen planus |
| title | Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis |
| title_full | Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis |
| title_fullStr | Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis |
| title_full_unstemmed | Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis |
| title_short | Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis |
| title_sort | vitamin d receptor gene polymorphism in oral cancer as a function of tobacco consumption an evidence based systematic review and meta analysis |
| topic | VDR gene vitamin D tobacco oral cancer oral lichen planus |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1550683/full |
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