Influence of Hypoxia on Tumor Heterogeneity, DNA Repair, and Cancer Therapy: From Molecular Insights to Therapeutic Strategies

Influence of Hypoxia on Tumor Heterogeneity, DNA Repair, and Cancer Therapy: From Molecular Insights to Therapeutic Strategies

Hypoxia, characterized by a reduction in tissue oxygen levels, is a hallmark of many solid tumors and affects a range of cellular processes, including DNA repair. In low-oxygen conditions, cancer cells often suppress key DNA repair pathways such as homologous recombination (HR), leading to the accum...

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Bibliographic Details
Main Authors: Dominika Kunachowicz, Paulina Tomecka, Mikołaj Sędzik, Jarosław Kalinin, Jacek Kuźnicki, Nina Rembiałkowska
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
hypoxia
cancer
tumor heterogeneity
DNA repair
cancer therapy
therapeutic resistance
Online Access:https://www.mdpi.com/2073-4409/14/14/1057
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