Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study
Background We investigated the association between body composition changes and new-onset diabetes mellitus (DM) development according to the body mass index (BMI) in a longitudinal setting in the general Korean population. Methods From 2010 to 2011 (1st) and 2012 to 2013 (2nd), we included 1,607,50...
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| Language: | English |
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Korean Diabetes Association
2024-11-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://e-dmj.org/upload/pdf/dmj-2023-0243.pdf |
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| author | Hyung Jun Kim Hyung-Woo Lee Min-Kyoung Kang Gwang Hyun Leem Min-Ho Kim Tae-Jin Song |
| author_facet | Hyung Jun Kim Hyung-Woo Lee Min-Kyoung Kang Gwang Hyun Leem Min-Ho Kim Tae-Jin Song |
| author_sort | Hyung Jun Kim |
| collection | DOAJ |
| description | Background We investigated the association between body composition changes and new-onset diabetes mellitus (DM) development according to the body mass index (BMI) in a longitudinal setting in the general Korean population. Methods From 2010 to 2011 (1st) and 2012 to 2013 (2nd), we included 1,607,508 stratified random sample participants without DM from the National Health Insurance Service-Health Screening dataset of Korean. The predicted appendicular skeletal muscle mass index (pASMMI), body fat mass index (pBFMI), and lean body mass index (pLBMI) were calculated using pre-validated anthropometric prediction equations. A prediction equation was constructed by combining age, weight, height, waist circumference, serum creatinine levels, alcohol consumption status, physical activity, and smoking history as variables affecting body composition. Results Decreased pASMMI (men: hazard ratio [HR], 0.866; 95% confidence interval [CI], 0.830 to 0.903; P<0.001; women: HR, 0.748; 95% CI, 0.635 to 0.881; P<0.001), decreased pLBMI (men: HR, 0.931; 95% CI, 0.912 to 0.952; P<0.001; women: HR, 0.906; 95% CI, 0.856 to 0.959; P=0.007), and increased pBFMI (men: HR, 1.073; 95% CI, 1.050 to 1.096; P<0.001; women: HR, 1.114; 95% CI, 1.047 to 1.186; P=0.007) correlated with the development of new-onset DM. Notably, only in the overweight and obese BMI categories, decreases in pASMMI and pLBMI and increases in pBFMI associated with new-onset DM, regardless of gender. Conclusion Decreased pASMMI and pLBMI, and increased pBFMI with excess fat accumulation may enhance the risk of newonset DM. Therefore, appropriate changes in body composition can help prevent new-onset DM. |
| format | Article |
| id | doaj-art-7367153600a141eda9058443b009e083 |
| institution | DOAJ |
| issn | 2233-6079 2233-6087 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj-art-7367153600a141eda9058443b009e0832025-08-20T02:48:53ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872024-11-014861093110410.4093/dmj.2023.02432848Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population StudyHyung Jun Kim0Hyung-Woo Lee1Min-Kyoung Kang2Gwang Hyun Leem3Min-Ho Kim4Tae-Jin Song5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea Medical Research Institute, Ewha Womans University, Seoul, Korea Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, KoreaBackground We investigated the association between body composition changes and new-onset diabetes mellitus (DM) development according to the body mass index (BMI) in a longitudinal setting in the general Korean population. Methods From 2010 to 2011 (1st) and 2012 to 2013 (2nd), we included 1,607,508 stratified random sample participants without DM from the National Health Insurance Service-Health Screening dataset of Korean. The predicted appendicular skeletal muscle mass index (pASMMI), body fat mass index (pBFMI), and lean body mass index (pLBMI) were calculated using pre-validated anthropometric prediction equations. A prediction equation was constructed by combining age, weight, height, waist circumference, serum creatinine levels, alcohol consumption status, physical activity, and smoking history as variables affecting body composition. Results Decreased pASMMI (men: hazard ratio [HR], 0.866; 95% confidence interval [CI], 0.830 to 0.903; P<0.001; women: HR, 0.748; 95% CI, 0.635 to 0.881; P<0.001), decreased pLBMI (men: HR, 0.931; 95% CI, 0.912 to 0.952; P<0.001; women: HR, 0.906; 95% CI, 0.856 to 0.959; P=0.007), and increased pBFMI (men: HR, 1.073; 95% CI, 1.050 to 1.096; P<0.001; women: HR, 1.114; 95% CI, 1.047 to 1.186; P=0.007) correlated with the development of new-onset DM. Notably, only in the overweight and obese BMI categories, decreases in pASMMI and pLBMI and increases in pBFMI associated with new-onset DM, regardless of gender. Conclusion Decreased pASMMI and pLBMI, and increased pBFMI with excess fat accumulation may enhance the risk of newonset DM. Therefore, appropriate changes in body composition can help prevent new-onset DM.http://e-dmj.org/upload/pdf/dmj-2023-0243.pdfbody compositiondiabetes mellitus, type 2korean populationsarcopenia |
| spellingShingle | Hyung Jun Kim Hyung-Woo Lee Min-Kyoung Kang Gwang Hyun Leem Min-Ho Kim Tae-Jin Song Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study Diabetes & Metabolism Journal body composition diabetes mellitus, type 2 korean population sarcopenia |
| title | Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study |
| title_full | Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study |
| title_fullStr | Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study |
| title_full_unstemmed | Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study |
| title_short | Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study |
| title_sort | association of body composition changes with the development of diabetes mellitus a nation wide population study |
| topic | body composition diabetes mellitus, type 2 korean population sarcopenia |
| url | http://e-dmj.org/upload/pdf/dmj-2023-0243.pdf |
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