Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma
Lung cancer is one of the most common malignant tumors, and patients are often diagnosed at an advanced stage, posing a substantial risk to human health, so it is crucial to establish a model to forecast the prognosis of patients with lung cancer. Recent research has indicated that proteasome 20S su...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1458047/full |
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| author | Haiyang Zhao Haiyang Zhao Haiyang Zhao Haiyang Zhao Kexin Luo Kexin Luo Kexin Luo Kexin Luo Meihan Liu Meihan Liu Meihan Liu Meihan Liu Yuanze Cai Siman Liu Shijuan Li Yongsheng Zhao Yongsheng Zhao Yongsheng Zhao Hongpan Zhang Hongpan Zhang Hongpan Zhang Hongpan Zhang |
| author_facet | Haiyang Zhao Haiyang Zhao Haiyang Zhao Haiyang Zhao Kexin Luo Kexin Luo Kexin Luo Kexin Luo Meihan Liu Meihan Liu Meihan Liu Meihan Liu Yuanze Cai Siman Liu Shijuan Li Yongsheng Zhao Yongsheng Zhao Yongsheng Zhao Hongpan Zhang Hongpan Zhang Hongpan Zhang Hongpan Zhang |
| author_sort | Haiyang Zhao |
| collection | DOAJ |
| description | Lung cancer is one of the most common malignant tumors, and patients are often diagnosed at an advanced stage, posing a substantial risk to human health, so it is crucial to establish a model to forecast the prognosis of patients with lung cancer. Recent research has indicated that proteasome 20S subunit 6 (PSMB6) may be closely associated with anti-apoptotic pathways, and proliferation transduction signals in tumor cells of different tumors. However, the precise role of PSMB6 in the immunoregulatory processes within lung adenocarcinoma (LUAD) is yet to be elucidated. By analyzing the TCGA database, we discovered a positive correlation between the expression of PSMB6 and tumor growth trends, and lung adenocarcinoma patients with elevated PSMB6 expression levels had a worse prognosis. Our findings suggest a close correlation between PSMB6 expression levels, immune cell infiltration and immune checkpoint gene expression, which suggests that PSMB6 may become a new independent prognostic indicator. In addition, we developed a prognostic model of PSMB6-regulated immune infiltration-associated genes by analyzing the link between PSMB6 and the immune microenvironment. This model can not only predict the prognosis of lung adenocarcinoma but also forecasts the patient’s reaction to immunotherapy. The validity of this research outcome has been confirmed by the GSE31210 and IMvigor210 cohorts. Analysis of the Kaplan-Meier Plotter database indicates that individuals with elevated levels of PSMB6 expression exhibit a poorer prognosis. Additionally, in vitro experiments demonstrated that knockdown of PSMB6 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells while promoting their apoptosis. Overall, our findings suggest that PSMB6 could remarkably influence the management and treatment of lung adenocarcinoma, opening new avenues for targeted immunotherapeutic strategies. |
| format | Article |
| id | doaj-art-735d040537714b3384b669df5503eb4f |
| institution | DOAJ |
| issn | 1664-8021 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-735d040537714b3384b669df5503eb4f2025-08-20T02:50:36ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-10-011510.3389/fgene.2024.14580471458047Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinomaHaiyang Zhao0Haiyang Zhao1Haiyang Zhao2Haiyang Zhao3Kexin Luo4Kexin Luo5Kexin Luo6Kexin Luo7Meihan Liu8Meihan Liu9Meihan Liu10Meihan Liu11Yuanze Cai12Siman Liu13Shijuan Li14Yongsheng Zhao15Yongsheng Zhao16Yongsheng Zhao17Hongpan Zhang18Hongpan Zhang19Hongpan Zhang20Hongpan Zhang21Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Nanchong, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Innovation Centre for Science and Technology, Nanchong, ChinaAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Nanchong, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Innovation Centre for Science and Technology, Nanchong, ChinaAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Innovation Centre for Science and Technology, Nanchong, ChinaDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNorth Sichuan Medical College, Nanchong, ChinaNanchong Central Hospital, Nanchong, Sichuan, ChinaAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Nanchong, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaNorth Sichuan Medical College, Nanchong, ChinaDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaTherapeutic Proteins Key Laboratory of Sichuan Province, Nanchong, ChinaLung cancer is one of the most common malignant tumors, and patients are often diagnosed at an advanced stage, posing a substantial risk to human health, so it is crucial to establish a model to forecast the prognosis of patients with lung cancer. Recent research has indicated that proteasome 20S subunit 6 (PSMB6) may be closely associated with anti-apoptotic pathways, and proliferation transduction signals in tumor cells of different tumors. However, the precise role of PSMB6 in the immunoregulatory processes within lung adenocarcinoma (LUAD) is yet to be elucidated. By analyzing the TCGA database, we discovered a positive correlation between the expression of PSMB6 and tumor growth trends, and lung adenocarcinoma patients with elevated PSMB6 expression levels had a worse prognosis. Our findings suggest a close correlation between PSMB6 expression levels, immune cell infiltration and immune checkpoint gene expression, which suggests that PSMB6 may become a new independent prognostic indicator. In addition, we developed a prognostic model of PSMB6-regulated immune infiltration-associated genes by analyzing the link between PSMB6 and the immune microenvironment. This model can not only predict the prognosis of lung adenocarcinoma but also forecasts the patient’s reaction to immunotherapy. The validity of this research outcome has been confirmed by the GSE31210 and IMvigor210 cohorts. Analysis of the Kaplan-Meier Plotter database indicates that individuals with elevated levels of PSMB6 expression exhibit a poorer prognosis. Additionally, in vitro experiments demonstrated that knockdown of PSMB6 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells while promoting their apoptosis. Overall, our findings suggest that PSMB6 could remarkably influence the management and treatment of lung adenocarcinoma, opening new avenues for targeted immunotherapeutic strategies.https://www.frontiersin.org/articles/10.3389/fgene.2024.1458047/fulllung adenocarcinomaPSMB6immunotherapyimmune infiltrationtumor immune microenvironment |
| spellingShingle | Haiyang Zhao Haiyang Zhao Haiyang Zhao Haiyang Zhao Kexin Luo Kexin Luo Kexin Luo Kexin Luo Meihan Liu Meihan Liu Meihan Liu Meihan Liu Yuanze Cai Siman Liu Shijuan Li Yongsheng Zhao Yongsheng Zhao Yongsheng Zhao Hongpan Zhang Hongpan Zhang Hongpan Zhang Hongpan Zhang Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma Frontiers in Genetics lung adenocarcinoma PSMB6 immunotherapy immune infiltration tumor immune microenvironment |
| title | Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma |
| title_full | Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma |
| title_fullStr | Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma |
| title_full_unstemmed | Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma |
| title_short | Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma |
| title_sort | immune regulation and prognostic prediction model establishment and validation of psmb6 in lung adenocarcinoma |
| topic | lung adenocarcinoma PSMB6 immunotherapy immune infiltration tumor immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1458047/full |
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