Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage
We present the results of bronchoalveolar lavage (BAL) performed in three patients with severe influenza A/H1N1 pneumonia complicated by acute respiratory distress syndrome (ARDS). Light microscopy analysis of BAL cytocentrifugates showed the presence of characteristic large, mononuclear, plasmoblas...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/470825 |
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| author | Paola Faverio Stefano Aliberti Clinton Ezekiel Grazia Messinesi Ambrogio Brenna Alberto Pesci |
| author_facet | Paola Faverio Stefano Aliberti Clinton Ezekiel Grazia Messinesi Ambrogio Brenna Alberto Pesci |
| author_sort | Paola Faverio |
| collection | DOAJ |
| description | We present the results of bronchoalveolar lavage (BAL) performed in three patients with severe influenza A/H1N1 pneumonia complicated by acute respiratory distress syndrome (ARDS). Light microscopy analysis of BAL cytocentrifugates showed the presence of characteristic large, mononuclear, plasmoblastic/plasmocytoid-like cells never described before. Via transmission electron microscopy, these cells were classified as atypical type II pneumocytes and some of them showed cytoplasmic vesicles and inclusions. We concluded that plasmoblastic/plasmocytoid-like type II pneumocytes might represent a morphologic marker of A/H1N1 influenza virus infection as well as reparative cellular activation after diffuse alveolar damage. |
| format | Article |
| id | doaj-art-735aaecc33a34226818515baa3994d19 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-735aaecc33a34226818515baa3994d192025-02-03T01:20:25ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/470825470825Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar LavagePaola Faverio0Stefano Aliberti1Clinton Ezekiel2Grazia Messinesi3Ambrogio Brenna4Alberto Pesci5Department of Health Science, University of Milan Bicocca, Clinica Pneumologica, AO San Gerardo, Via Pergolesi 33, 20900 Monza, ItalyDepartment of Health Science, University of Milan Bicocca, Clinica Pneumologica, AO San Gerardo, Via Pergolesi 33, 20900 Monza, ItalyUniversity of Texas Health Science Center at San Antonio, 8300 Floyd Curl Drive, San Antonio, TX 78229, USADepartment of Health Science, University of Milan Bicocca, Clinica Pneumologica, AO San Gerardo, Via Pergolesi 33, 20900 Monza, ItalyAnatomia Patologica, AO San Gerardo, Via Pergolesi 33, 20900 Monza, ItalyDepartment of Health Science, University of Milan Bicocca, Clinica Pneumologica, AO San Gerardo, Via Pergolesi 33, 20900 Monza, ItalyWe present the results of bronchoalveolar lavage (BAL) performed in three patients with severe influenza A/H1N1 pneumonia complicated by acute respiratory distress syndrome (ARDS). Light microscopy analysis of BAL cytocentrifugates showed the presence of characteristic large, mononuclear, plasmoblastic/plasmocytoid-like cells never described before. Via transmission electron microscopy, these cells were classified as atypical type II pneumocytes and some of them showed cytoplasmic vesicles and inclusions. We concluded that plasmoblastic/plasmocytoid-like type II pneumocytes might represent a morphologic marker of A/H1N1 influenza virus infection as well as reparative cellular activation after diffuse alveolar damage.http://dx.doi.org/10.1155/2014/470825 |
| spellingShingle | Paola Faverio Stefano Aliberti Clinton Ezekiel Grazia Messinesi Ambrogio Brenna Alberto Pesci Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage Interdisciplinary Perspectives on Infectious Diseases |
| title | Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage |
| title_full | Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage |
| title_fullStr | Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage |
| title_full_unstemmed | Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage |
| title_short | Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage |
| title_sort | influenza a h1n1 severe pneumonia novel morphocytological findings in bronchoalveolar lavage |
| url | http://dx.doi.org/10.1155/2014/470825 |
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