The Impact of Chronic Pain on Cognitive Function

The Impact of Chronic Pain on Cognitive Function

<b>Background</b>: Chronic pain affects a significant proportion of the population in the United States and poses a significant public health concern. Beyond physical discomfort, chronic pain has been increasingly linked to cognitive dysfunction, including impairments in memory, attentio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Milan Patel, Jamal Hasoon, Rodrigo Diez Tafur, Giuliano Lo Bianco, Alaa Abd-Elsayed
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Brain Sciences
Subjects:	chronic pain cognitive dysfunction neuroinflammation gray matter atrophy depression Alzheimer’s disease
Online Access:	https://www.mdpi.com/2076-3425/15/6/559
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease
by: Kerstin Schweyer, et al.
Published: (2025-05-01)

Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods
by: Yuhao ZHANG, et al.
Published: (2020-08-01)

Critical analysis on the present methods for brain volume measurements in multiple sclerosis
by: Yara Dadalti Fragoso, et al.

Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank
by: Panlong Li, et al.
Published: (2025-06-01)

Association between white matter hyperintensities and gray matter volume in cerebral small vessel disease: insights from periventricular and deep white matter lesions
by: Weishun Feng, et al.
Published: (2025-07-01)

Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease
by: Ali Azargoonjahromi, et al.
Published: (2024-12-01)

Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults
by: Hao Shu, et al.
Published: (2025-01-01)

Mastication Influences Human Brain Anatomy
by: Lucia Lopez-Chaichio, et al.
Published: (2024-12-01)

Glial Cells in Spinal Muscular Atrophy: Speculations on Non-Cell-Autonomous Mechanisms and Therapeutic Implications
by: Andrej Belančić, et al.
Published: (2025-03-01)

Gray matter morphology and pain-related disability in young adults with low back pain
by: Jo Armour Smith, et al.
Published: (2025-05-01)

Dietary fiber intake and hippocampal gray matter volume: an exploratory cross-sectional study in healthy adults
by: Raghav Pallapothu, et al.
Published: (2025-06-01)

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways
by: Waqas Ahmad, et al.
Published: (2025-07-01)

Early prediction of Alzheimer’s disease using artificial intelligence and cortical features on T1WI sequences
by: Rong Zeng, et al.
Published: (2025-03-01)

Enhanced particle swarm optimization for feature selection in SVM-based Alzheimer’s disease diagnosis
by: Qian Zhang, et al.
Published: (2025-07-01)

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection
by: Juanjuan Jiang, et al.
Published: (2025-07-01)

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
by: Yuan Gao, et al.
Published: (2025-07-01)

Consistent genes associated with structural changes in clinical Alzheimer’s disease spectrum
by: Yingqi Lu, et al.
Published: (2024-11-01)

Reorganization of gray matter networks in patients with Moyamoya disease
by: Huan Zhu, et al.
Published: (2025-01-01)

Structural brain alterations in patients with anxious depression: evidence from the REST-meta-MDD project
by: Songhao Hu, et al.
Published: (2025-07-01)

JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation
by: Shuyan Wu, et al.
Published: (2025-02-01)

Nanozymes in neuropathic pain: strategies bridging oxidative stress, mitochondrial repair, and neuroimmune modulation for targeted therapy
by: Muhammad Mohsin, et al.
Published: (2025-06-01)

Hearing loss and its relation to cognition in Indian cohort: A behavioral and neuroimaging study
by: Deepashri Agrawal, et al.
Published: (2025-04-01)

Abnormal structural covariance network in major depressive disorder: Evidence from the REST-meta-MDD project
by: Changmin Chen, et al.
Published: (2025-01-01)

Neuroimaging-Based Brain Morphometry in Alzheimer’s Disease
by: Nonyelum Aniebo, et al.
Published: (2024-10-01)

Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
by: Qiong Wang, et al.
Published: (2024-12-01)

An analysis of minimal depressive symptoms and minimal anxiety symptoms in patients with subjective cognitive decline
by: CUI Ruiping, GAO Peiyang, CHEN Yanming, WANG Yudong, TAN Mengshan, TAN Lan
Published: (2025-04-01)

Efficacy and brain modulation mechanisms of acupuncture for chronic prostatitis/chronic pelvic pain syndrome revealed by structural MRI changes
by: Zhen Wang, et al.
Published: (2025-06-01)

Cognitive dysfunction in patients with non-alcoholic fatty liver disease
by: S. A. Smakotina, et al.
Published: (2025-06-01)

Effect Observation of Baduanjin Training on Chronic Nonspecific Low Back Pain
by: Feng GAO, et al.
Published: (2018-08-01)

Delphinidin attenuates cognitive deficits and pathology of Alzheimer’s disease by preventing microglial senescence via AMPK/SIRT1 pathway
by: Ying Liu, et al.
Published: (2025-06-01)

Hippocampal gray matter volume alterations in patients with first-episode and recurrent major depressive disorder and their associations with gene profiles
by: Fenfen Sun, et al.
Published: (2025-02-01)

No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population
by: A. Lamé, et al.
Published: (2025-01-01)

Concurrent validity of Thai version of pain assessment in advanced dementia scale versus self reported pain in cognitively impaired and intact geriatric surgical patients
by: Sahatsa Mandee, et al.
Published: (2025-08-01)

The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study
by: Cheryl R.Z. See, et al.
Published: (2025-01-01)

Generalized Cortical Dysplasia
by: J Gordon Millichap
Published: (1991-08-01)

Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin
by: YANG Le, et al.
Published: (2025-06-01)

Redox reactions in chronic pain: mechanisms and relevance in fibromyalgia
by: Tim Ho, et al.
Published: (2025-05-01)

Decoding pain chronification: mechanisms of the acute-to-chronic transition
by: Shunwei Zhang, et al.
Published: (2025-06-01)

The emerging role of exercise preconditioning in preventing skeletal muscle atrophy
by: Xu Zhou, et al.
Published: (2025-03-01)

Lead-induced hypertension and cognitive dysfunction: brain amyloid pathology
by: Yunbo Zhang, et al.
Published: (2025-08-01)