Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study
Abstract Background Uncut Roux-en-Y (URY) effectively alleviates the prevalent complexities connected with RY, such as Roux-en-Y stasis syndrome (RSS). Nevertheless, for gastric cancer (GC) patients, it is still controversial whether URY has an impact on long-term prognosis and whether it has fewer...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-023-03154-y |
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| author | Yizhen Chen Yuanyuan Zheng Song Tan Yifan Chen Tao Zheng Shaolin Liu Yulong Mi Shentao Lin Changshun Yang Jian Jiang Weihua Li |
| author_facet | Yizhen Chen Yuanyuan Zheng Song Tan Yifan Chen Tao Zheng Shaolin Liu Yulong Mi Shentao Lin Changshun Yang Jian Jiang Weihua Li |
| author_sort | Yizhen Chen |
| collection | DOAJ |
| description | Abstract Background Uncut Roux-en-Y (URY) effectively alleviates the prevalent complexities connected with RY, such as Roux-en-Y stasis syndrome (RSS). Nevertheless, for gastric cancer (GC) patients, it is still controversial whether URY has an impact on long-term prognosis and whether it has fewer afferent loop recanalization. Therefore, compare whether URY and RY have differences in prognosis and long-term complications of GC patients undergoing totally laparoscopic gastrectomy (TLG). Methods We analyzed the data of patients who underwent TLG combined with digestive tract reconstruction from dual-center between 2016 and 2022. Only patients undergoing URY and RY were selected for analysis. Relapse-free survival (RFS) and overall survival (OS) were estimated. Bias between the groups was reduced by propensity score matching (PSM). The Cox proportional hazard regression model was used to further analyze the influence of URY on prognosis. Results Two hundred forty two GC patients were enrolled. The URY had significantly shorter operation time, liquid food intake time, and in-hospital stays than the RY (P < 0.001). The URY had fewer long-term and short-term postoperative complications than the RY, especially with regard to RSS, reflux esophagitis, and reflux gastritis. The 3-year and 5-year OS of the URY group and the RY group before PSM: 87.5% vs. 65.6% (P < 0.001) and 81.4% vs. 61.7% (P = 0.001). PSM and Cox multivariate analysis confirmed that compared to RY, URY can improve the short-term and long-term prognosis of GC patients. Conclusion TLG combined with URY for GC, especially for advanced, older, and poorly differentiated patients, may promote postoperative recovery and improve long-term prognosis. |
| format | Article |
| id | doaj-art-735874dbb6fd48b8b0b6dfa9a6fadeb3 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-735874dbb6fd48b8b0b6dfa9a6fadeb32025-08-20T03:26:43ZengBMCWorld Journal of Surgical Oncology1477-78192023-09-0121111210.1186/s12957-023-03154-yEfficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective studyYizhen Chen0Yuanyuan Zheng1Song Tan2Yifan Chen3Tao Zheng4Shaolin Liu5Yulong Mi6Shentao Lin7Changshun Yang8Jian Jiang9Weihua Li10Shengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityDepartment of Surgical Oncology, Fujian Provincial HospitalDepartment of Surgical Oncology, Fujian Provincial HospitalDepartment of Surgical Oncology, Fujian Provincial HospitalThe School of Public Health, Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityAbstract Background Uncut Roux-en-Y (URY) effectively alleviates the prevalent complexities connected with RY, such as Roux-en-Y stasis syndrome (RSS). Nevertheless, for gastric cancer (GC) patients, it is still controversial whether URY has an impact on long-term prognosis and whether it has fewer afferent loop recanalization. Therefore, compare whether URY and RY have differences in prognosis and long-term complications of GC patients undergoing totally laparoscopic gastrectomy (TLG). Methods We analyzed the data of patients who underwent TLG combined with digestive tract reconstruction from dual-center between 2016 and 2022. Only patients undergoing URY and RY were selected for analysis. Relapse-free survival (RFS) and overall survival (OS) were estimated. Bias between the groups was reduced by propensity score matching (PSM). The Cox proportional hazard regression model was used to further analyze the influence of URY on prognosis. Results Two hundred forty two GC patients were enrolled. The URY had significantly shorter operation time, liquid food intake time, and in-hospital stays than the RY (P < 0.001). The URY had fewer long-term and short-term postoperative complications than the RY, especially with regard to RSS, reflux esophagitis, and reflux gastritis. The 3-year and 5-year OS of the URY group and the RY group before PSM: 87.5% vs. 65.6% (P < 0.001) and 81.4% vs. 61.7% (P = 0.001). PSM and Cox multivariate analysis confirmed that compared to RY, URY can improve the short-term and long-term prognosis of GC patients. Conclusion TLG combined with URY for GC, especially for advanced, older, and poorly differentiated patients, may promote postoperative recovery and improve long-term prognosis.https://doi.org/10.1186/s12957-023-03154-yGastric cancerTotally laparoscopic gastrectomyUncut Roux-en-YDigestive tract reconstruction |
| spellingShingle | Yizhen Chen Yuanyuan Zheng Song Tan Yifan Chen Tao Zheng Shaolin Liu Yulong Mi Shentao Lin Changshun Yang Jian Jiang Weihua Li Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study World Journal of Surgical Oncology Gastric cancer Totally laparoscopic gastrectomy Uncut Roux-en-Y Digestive tract reconstruction |
| title | Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study |
| title_full | Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study |
| title_fullStr | Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study |
| title_full_unstemmed | Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study |
| title_short | Efficacy and safety of totally laparoscopic gastrectomy with uncut Roux-en-Y for gastric cancer: a dual-center retrospective study |
| title_sort | efficacy and safety of totally laparoscopic gastrectomy with uncut roux en y for gastric cancer a dual center retrospective study |
| topic | Gastric cancer Totally laparoscopic gastrectomy Uncut Roux-en-Y Digestive tract reconstruction |
| url | https://doi.org/10.1186/s12957-023-03154-y |
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