Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells.

There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that parenteral vaccination with a carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cell responses to subunit antigens and afforded effec...

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Bibliographic Details
Main Authors:	Woojong Lee, Brock Kingstad-Bakke, Brett Paulson, Autumn Larsen, Katherine Overmyer, Chandranaik B Marinaik, Kelly Dulli, Randall Toy, Gabriela Vogel, Katherine P Mueller, Kelsey Tweed, Alex J Walsh, Jason Russell, Krishanu Saha, Leticia Reyes, Melissa C Skala, John-Demian Sauer, Dmitry M Shayakhmetov, Joshua Coon, Krishnendu Roy, M Suresh
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-01-01
Series:	PLoS Pathogens
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009168&type=printable
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Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells.

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