Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis
The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014.Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolates from 151 pulmonary...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2024-03-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1792 |
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| author | P. K. Yablonskiy B. I. Vishnevskiy N. S. Solovyova V. B. Galkin |
| author_facet | P. K. Yablonskiy B. I. Vishnevskiy N. S. Solovyova V. B. Galkin |
| author_sort | P. K. Yablonskiy |
| collection | DOAJ |
| description | The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014.Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolates from 151 pulmonary tuberculosis (PTB) patients and isolates from 805 extrapulmonary tuberculosis (EPTB) patients, who were treated at the clinic of St. Petersburg Research Institute of Phthisiopulmonology in 2015-2021. The results were compared with similar data for 2012-2014 which was published in 2016.Results. In 2015-2021 versus 2012-2014, the overall frequency of MTB DR decreased by 4.2% in pulmonary tuberculosis patients (from 90.1 to 85.9%) and by 2.9% in extrapulmonary tuberculosis patients (from 80.2 to 77.4%). The structure of MTB DR in pulmonary tuberculosis changed insignificantly, the frequency of MDR decreased from 42.5 to 36.5%, and XDR (as per the definitions before 2022) remained the same – 39.5%. In extrapulmonary tuberculosis, the structure of MTB DR deteriorated due to lower frequency of MDR (from 66.3 to 48.3%) and higher frequency of XDR (from 3.2 to 19.0%, p<0.01). |
| format | Article |
| id | doaj-art-735328264e5c4e868008dad23ec4783f |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2024-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-735328264e5c4e868008dad23ec4783f2025-08-20T01:47:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062024-03-011021404510.58838/2075-1230-2024-102-1-40-451787Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary TuberculosisP. K. Yablonskiy0B. I. Vishnevskiy1N. S. Solovyova2V. B. Galkin3St. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health; St. Petersburg UniversitySt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of HealthSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of HealthSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of HealthThe objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014.Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolates from 151 pulmonary tuberculosis (PTB) patients and isolates from 805 extrapulmonary tuberculosis (EPTB) patients, who were treated at the clinic of St. Petersburg Research Institute of Phthisiopulmonology in 2015-2021. The results were compared with similar data for 2012-2014 which was published in 2016.Results. In 2015-2021 versus 2012-2014, the overall frequency of MTB DR decreased by 4.2% in pulmonary tuberculosis patients (from 90.1 to 85.9%) and by 2.9% in extrapulmonary tuberculosis patients (from 80.2 to 77.4%). The structure of MTB DR in pulmonary tuberculosis changed insignificantly, the frequency of MDR decreased from 42.5 to 36.5%, and XDR (as per the definitions before 2022) remained the same – 39.5%. In extrapulmonary tuberculosis, the structure of MTB DR deteriorated due to lower frequency of MDR (from 66.3 to 48.3%) and higher frequency of XDR (from 3.2 to 19.0%, p<0.01).https://www.tibl-journal.com/jour/article/view/1792mycobacterium tuberculosispulmonary tuberculosisextrapulmonary tuberculosisdrug resistance of mtbmdrxdr |
| spellingShingle | P. K. Yablonskiy B. I. Vishnevskiy N. S. Solovyova V. B. Galkin Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis Туберкулез и болезни лёгких mycobacterium tuberculosis pulmonary tuberculosis extrapulmonary tuberculosis drug resistance of mtb mdr xdr |
| title | Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis |
| title_full | Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis |
| title_fullStr | Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis |
| title_full_unstemmed | Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis |
| title_short | Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis |
| title_sort | frequency and structure of drug resistance of m tuberculosis in pulmonary and extrapulmonary tuberculosis |
| topic | mycobacterium tuberculosis pulmonary tuberculosis extrapulmonary tuberculosis drug resistance of mtb mdr xdr |
| url | https://www.tibl-journal.com/jour/article/view/1792 |
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