Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study
Glomerular diseases are a major cause of chronic kidney disease worldwide, yet epidemiological data from Eastern Europe, and Romania in particular, remain scarce. This study aimed to characterize the spectrum of biopsy-proven glomerulopathies in Romania through a multicenter national registry over a...
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MDPI AG
2025-06-01
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| author | Andreea Covic Mihai Onofriescu Flaviu R. Bob Cristina Căpușă Irina-Draga Căruntu Otilia Ciurea Adrian Covic Simona Giusca Ina Kacso Adelina Mihăescu Andreea Niculescu Bogdan Obrișcă Dacian Tirinescu Adalbert Schiller Alexandra Vrabie Yuriy Maslyennikov Gener Ismail |
| author_facet | Andreea Covic Mihai Onofriescu Flaviu R. Bob Cristina Căpușă Irina-Draga Căruntu Otilia Ciurea Adrian Covic Simona Giusca Ina Kacso Adelina Mihăescu Andreea Niculescu Bogdan Obrișcă Dacian Tirinescu Adalbert Schiller Alexandra Vrabie Yuriy Maslyennikov Gener Ismail |
| author_sort | Andreea Covic |
| collection | DOAJ |
| description | Glomerular diseases are a major cause of chronic kidney disease worldwide, yet epidemiological data from Eastern Europe, and Romania in particular, remain scarce. This study aimed to characterize the spectrum of biopsy-proven glomerulopathies in Romania through a multicenter national registry over a 10-year period. We retrospectively analyzed 4047 native kidney biopsies performed between 2014 and 2023 across four national nephrology reference centers. Patient demographics, clinical presentation, and histopathological diagnoses were collected and categorized into primary and secondary glomerular diseases, glomerulosclerosis, tubulointerstitial nephropathies, hereditary nephropathies, and vascular nephropathies. The mean patient age was 48 years, 54.8% were male, and 51.4% presented with nephrotic-range proteinuria. The most common primary glomerulopathies were membranous nephropathy (16.7%), immunoglobulin A nephropathy (15.6%), focal segmental glomerulosclerosis (8.8%), and membranoproliferative glomerulonephritis (10%). Among secondary glomerular diseases, lupus nephritis (9.3%), diabetic nephropathy (8.5%), and vasculitis (7.7%) were most frequent. Marked inter-center variability was observed, with a notably high prevalence of membranous nephropathy in Iași (31.1%). Over the study period, the incidence of focal segmental glomerulosclerosis increased while immunoglobulin A nephropathy declined. This study provides the first nationwide epidemiological assessment of biopsy-proven glomerular disease in Romania, revealing both similarities and distinctive differences compared to patterns reported in other European countries. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-734ef3bc521c40e09b14eb44ed4e7cc62025-08-20T03:16:33ZengMDPI AGLife2075-17292025-06-0115693810.3390/life15060938Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide StudyAndreea Covic0Mihai Onofriescu1Flaviu R. Bob2Cristina Căpușă3Irina-Draga Căruntu4Otilia Ciurea5Adrian Covic6Simona Giusca7Ina Kacso8Adelina Mihăescu9Andreea Niculescu10Bogdan Obrișcă11Dacian Tirinescu12Adalbert Schiller13Alexandra Vrabie14Yuriy Maslyennikov15Gener Ismail16Department of Nephrology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaDepartment of Nephrology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaDepartment of Nephrology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaDepartment of Nephrology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaClinical Hospital “Dr. C. I. Parhon”, 700503 Iași, RomaniaDepartment of Nephrology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Nephrology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaClinical Hospital “Dr. C. I. Parhon”, 700503 Iași, RomaniaDepartment of Nephrology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Nephrology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania“Dr. Carol Davila” Clinical Hospital of Nephrology, 010731 Bucharest, Romania“Dr. Carol Davila” Clinical Hospital of Nephrology, 010731 Bucharest, RomaniaDepartment of Nephrology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Nephrology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania“Dr. Carol Davila” Clinical Hospital of Nephrology, 010731 Bucharest, RomaniaDepartment of Nephrology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania“Dr. Carol Davila” Clinical Hospital of Nephrology, 010731 Bucharest, RomaniaGlomerular diseases are a major cause of chronic kidney disease worldwide, yet epidemiological data from Eastern Europe, and Romania in particular, remain scarce. This study aimed to characterize the spectrum of biopsy-proven glomerulopathies in Romania through a multicenter national registry over a 10-year period. We retrospectively analyzed 4047 native kidney biopsies performed between 2014 and 2023 across four national nephrology reference centers. Patient demographics, clinical presentation, and histopathological diagnoses were collected and categorized into primary and secondary glomerular diseases, glomerulosclerosis, tubulointerstitial nephropathies, hereditary nephropathies, and vascular nephropathies. The mean patient age was 48 years, 54.8% were male, and 51.4% presented with nephrotic-range proteinuria. The most common primary glomerulopathies were membranous nephropathy (16.7%), immunoglobulin A nephropathy (15.6%), focal segmental glomerulosclerosis (8.8%), and membranoproliferative glomerulonephritis (10%). Among secondary glomerular diseases, lupus nephritis (9.3%), diabetic nephropathy (8.5%), and vasculitis (7.7%) were most frequent. Marked inter-center variability was observed, with a notably high prevalence of membranous nephropathy in Iași (31.1%). Over the study period, the incidence of focal segmental glomerulosclerosis increased while immunoglobulin A nephropathy declined. This study provides the first nationwide epidemiological assessment of biopsy-proven glomerular disease in Romania, revealing both similarities and distinctive differences compared to patterns reported in other European countries.https://www.mdpi.com/2075-1729/15/6/938renal biopsyglomerulonephritisepidemiologymembranous nephropathyfocal segmental glomerulosclerosisimmunoglobulin A nephropathy |
| spellingShingle | Andreea Covic Mihai Onofriescu Flaviu R. Bob Cristina Căpușă Irina-Draga Căruntu Otilia Ciurea Adrian Covic Simona Giusca Ina Kacso Adelina Mihăescu Andreea Niculescu Bogdan Obrișcă Dacian Tirinescu Adalbert Schiller Alexandra Vrabie Yuriy Maslyennikov Gener Ismail Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study Life renal biopsy glomerulonephritis epidemiology membranous nephropathy focal segmental glomerulosclerosis immunoglobulin A nephropathy |
| title | Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study |
| title_full | Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study |
| title_fullStr | Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study |
| title_full_unstemmed | Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study |
| title_short | Biopsy-Proven Glomerulopathies in Romania: A 10-Year Nationwide Study |
| title_sort | biopsy proven glomerulopathies in romania a 10 year nationwide study |
| topic | renal biopsy glomerulonephritis epidemiology membranous nephropathy focal segmental glomerulosclerosis immunoglobulin A nephropathy |
| url | https://www.mdpi.com/2075-1729/15/6/938 |
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